Intravitreal bevacizumab (Avastin) treatment of choroidal neovascularisation in patients with angioid streaks

被引:42
|
作者
Wiegand, T. W. [1 ,2 ]
Rogers, A. H. [1 ]
McCabe, F. [1 ,3 ]
Reichel, E. [1 ]
Duker, J. S. [1 ]
机构
[1] Tufts Med Ctr, New England Eye Ctr, Boston, MA USA
[2] Ophthalm Consultants Boston, Boston, MA USA
[3] Vitreo Retinal Associates, Worcester, MA USA
关键词
PHOTODYNAMIC THERAPY; PSEUDOXANTHOMA ELASTICUM; SECONDARY; VERTEPORFIN;
D O I
10.1136/bjo.2008.143461
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To evaluate the safety and efficacy of intravitreal bevacizumab (Avastin) as treatment for choroidal neovascularisation (CNV) associated with angioid streaks Methods: A non-randomised, interventional case series conducted on eyes with subfoveal CNV associated with angioid streaks. Intravitreal bevacizumab ( 1.25 mg in 0.05 ml) was injected into nine eyes of six patients between August 2005 and December 2007. Treatment efficacy was assessed based on pre- and post-treatment visual acuity and optical coherence tomography (OCT). Results: With a mean follow-up of 19 months (range 10 to 28 months), the best corrected visual acuity improved by three or more lines in four eyes (44.4%), remained within two lines of baseline in four eyes (44.4%) and decreased by three or more lines in one eye (11.1%). Central foveal thickness (CFT) measured by OCT decreased an average of 67.7 mu m ( range +11 to -175 mu m) with an average improvement in standardised change in macular thickening of 46.6% (range -12% to +84.5%). No injection-related complications or drug-related side effects were observed. Conclusions: Intravitreal bevazicumab for the treatment of subfoveal CNV secondary to angioid streaks mildly reduced central foveal thickness with a trend toward stabilisation of visual acuity. Additional follow-up and a larger patient cohort are needed to evaluate the long-term effects of this treatment.
引用
收藏
页码:47 / 51
页数:5
相关论文
共 50 条
  • [21] Intravitreal Bevacizumab in the Treatment of Choroidal Neovascular Membrane Due to Angioid Streaks
    Alagoz, Cengiz
    Alagoz, Nese
    Turan, Miray
    Ozkaya, Abdullah
    Yazici, Ahmet Taylan
    Cekic, Osman
    Demirok, Ahmet
    OPHTHALMOLOGICA, 2014, 232 : 35 - 35
  • [22] INTRAVITREAL BEVACIZUMAB IN THE TREATMENT OF CHOROIDAL NEOVASCULAR MEMBRANE DUE TO ANGIOID STREAKS
    Alagoz, Cengiz
    Alagoz, Nese
    Ozkaya, Abdullah
    Celik, Ugur
    Turan, Miray F.
    Yazici, Ahmet T.
    Cekic, Osman
    Demirok, Ahmet
    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2015, 35 (10): : 2001 - 2010
  • [23] Intravitreal Bevacizumab for Nonsubfoveal Choroidal Neovascularization Associated With Angioid Streaks
    Parodi, Maurizio Battaglia
    Iacono, Pierluigi
    La Spina, Carlo
    Berchicci, Luigi
    Scotti, Fabrizio
    Leys, Anita
    Introini, Ugo
    Bandello, Francesco
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 2014, 157 (02) : 374 - 377
  • [24] Intravitreal bevacizumab (Avastin) as treatment for subfoveal choroidal neovascularisation secondary to pathological myopia
    Yamamoto, Izumi
    Rogers, Adam H.
    Reichel, Elias
    Yates, Paul A.
    Duker, Jay S.
    BRITISH JOURNAL OF OPHTHALMOLOGY, 2007, 91 (02) : 157 - 160
  • [25] Intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks: A report of two patients
    Ozkaya, Abdullah
    Alkin, Zeynep
    Faiz, Miray
    Yazici, Ahmet Taylan
    Demirok, Ahmet
    SAUDI JOURNAL OF OPHTHALMOLOGY, 2014, 28 (04) : 316 - 318
  • [26] Intravitreal Ranibizumab in the Treatment of Choroidal Neovascularization in Idiopathic Angioid Streaks Keywords: Ranibizumab, Angioid Streaks
    Gundogan, Fatih Cakir
    Yolcu, Umit
    Diner, Oktay
    OPHTHALMOLOGICA, 2014, 232 : 50 - 50
  • [27] Clinical Course of Choroidal Neovascularization Secondary to Angioid Streaks Treated With Intravitreal Bevacizumab
    Teixeira, Anderson
    Mattos, Tessa
    Velletri, Roberta
    Teixeira, Rafael
    Freire, Juliana
    Moares, Nilva
    Bonomo, Pedro Paulo
    OPHTHALMIC SURGERY LASERS & IMAGING, 2010, 41 (05) : 546 - 549
  • [28] Verteporfin photodynamic therapy for choroidal neovascularisation in angioid streaks
    Browning, AC
    Amoaku, WM
    Chung, AKK
    Ghanchi, F
    Harding, SP
    Gee, L
    Musadiq, M
    Yang, YC
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 : U80 - U80
  • [29] Intravitreal Ranibizumab for Choroidal Neovascularization in Angioid Streaks
    Mimoun, Gerard
    Tilleul, Julien
    Leys, Anita
    Coscas, Gabriel
    Soubrane, Gisele
    Souied, Eric H.
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 2010, 150 (05) : 692 - 700
  • [30] Intravitreal bevacizumab for the treatment of choroidal neovascularization secondary to angioid streaks: one year of follow-up
    El Matri, Leila
    Kort, Fedra
    Bouraoui, Rim
    Karim, Baklouti
    Chebil, Ahmed
    Chaker, Nibrass
    ACTA OPHTHALMOLOGICA, 2011, 89 (07) : 641 - 646