Objective: To evaluate the safety and efficacy of intravitreal bevacizumab (Avastin) as treatment for choroidal neovascularisation (CNV) associated with angioid streaks Methods: A non-randomised, interventional case series conducted on eyes with subfoveal CNV associated with angioid streaks. Intravitreal bevacizumab ( 1.25 mg in 0.05 ml) was injected into nine eyes of six patients between August 2005 and December 2007. Treatment efficacy was assessed based on pre- and post-treatment visual acuity and optical coherence tomography (OCT). Results: With a mean follow-up of 19 months (range 10 to 28 months), the best corrected visual acuity improved by three or more lines in four eyes (44.4%), remained within two lines of baseline in four eyes (44.4%) and decreased by three or more lines in one eye (11.1%). Central foveal thickness (CFT) measured by OCT decreased an average of 67.7 mu m ( range +11 to -175 mu m) with an average improvement in standardised change in macular thickening of 46.6% (range -12% to +84.5%). No injection-related complications or drug-related side effects were observed. Conclusions: Intravitreal bevazicumab for the treatment of subfoveal CNV secondary to angioid streaks mildly reduced central foveal thickness with a trend toward stabilisation of visual acuity. Additional follow-up and a larger patient cohort are needed to evaluate the long-term effects of this treatment.
机构:
Tufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USATufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USA
Yamamoto, Izumi
Rogers, Adam H.
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Tufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USATufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USA
Rogers, Adam H.
Reichel, Elias
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Tufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USATufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USA
Reichel, Elias
Yates, Paul A.
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Tufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USATufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USA
Yates, Paul A.
Duker, Jay S.
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Tufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USATufts Univ, Sch Med, New England Eye Ctr, New England Med Ctr, Boston, MA 02111 USA
机构:
Beyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, TurkeyBeyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, Turkey
Ozkaya, Abdullah
Alkin, Zeynep
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Beyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, TurkeyBeyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, Turkey
Alkin, Zeynep
Faiz, Miray
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Beyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, TurkeyBeyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, Turkey
Faiz, Miray
Yazici, Ahmet Taylan
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Beyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, TurkeyBeyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, Turkey
Yazici, Ahmet Taylan
Demirok, Ahmet
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Beyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, Turkey
Istanbul Medeniyet Univ, Istanbul, TurkeyBeyoglu Eye Res & Educ Hosp, Bereketzade Cami Sok 2, Istanbul, Turkey
机构:
Univ Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, France
Ecole Mil, Ctr Ophtalmol Imagerie, Paris, FranceUniv Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, France
Mimoun, Gerard
Tilleul, Julien
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Univ Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, FranceUniv Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, France
Tilleul, Julien
Leys, Anita
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Univ Hosp St Rafael, Dept Ophthalmol, Louvain, BelgiumUniv Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, France
Leys, Anita
Coscas, Gabriel
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Univ Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, FranceUniv Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, France
Coscas, Gabriel
Soubrane, Gisele
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Univ Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, FranceUniv Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, France
Soubrane, Gisele
Souied, Eric H.
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Univ Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, FranceUniv Paris 12, Hop Intercommunal Creteil, Dept Ophthalmol, Fac Med Henri Mondor, F-94000 Creteil, France