NH4Br-Promoted Single-Step and Transition-Metal-Free Conversion of Aldehydes to Nitriles in Ammonia Water

被引：0
|
作者：
Wang, Jin [1 ]
Yang, Xiao-Qin [1 ]
Li, Na [1 ]
Wang, Li. -Li [1 ]
机构：
[1] Yancheng Teachers Univ, Sch Pharm, Yancheng 224007, Jiangsu, Peoples R China
来源：
CHEMISTRYSELECT | 2022年 / 7卷 / 45期
关键词：
Aldehydes; Nitriles; Ammonia; Single-Step; Transition-Metal-Free; ONE-POT SYNTHESIS; OXIDATIVE CONVERSION; TRANSFORMATION; EFFICIENT; ALCOHOLS;
D O I：
10.1002/slct.202203982
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A green and general method for the direct transformation of aldehydes to nitriles was developed. This method features a broad scope of substrates including aromatic, heterocyclic, and aliphatic aldehydes, by using I-2/NH4Br in aqueous ammonia. Readily available aldehydes can be smoothly converted to corresponding nitriles in one-step under open air at room temperature for 1-12 hours. This protocol is transition-metal-free and could be applied for the synthesis of various key cyano (CN)-containing molecules.
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页数：4
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