Biosynthesis and Genetic Regulation of Proanthocyanidins in Plants

被引：163
作者：
He, Fei [1 ]
Pan, Qiu-Hong [1 ]
Shi, Ying [1 ]
Duan, Chang-Qing [1 ]
机构：
[1] China Agr Univ, Ctr Viticulture & Enol, Coll Food Sci & Nutrit Engn, Beijing 100083, Peoples R China
来源：
MOLECULES | 2008年 / 13卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Proanthocyanidins; Condensed Tannins; Structures; Flavonoid Biosynthesis; Transport Factors; Regulatory Genes;
D O I：
10.3390/molecules13102674
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proanthocyanidins (PAs), also known as condensed tannins, are a group of polyphenolic secondary metabolites synthesized in plants as oligomers or polymers of flavan-3-ol units via the flavonoid pathway. Due to their structural complexity and varied composition, only in the recent years has the study on the biosynthesis and regulation of PAs in plants taken off, although some details of the synthetic mechanism remain unclear. This paper aims to summarize the status of research on the structures of PAs in plants, the genes encoding key enzymes of biosynthetic pathway, the transport factors, the transcriptional regulation of PA biosynthesis and the genetic manipulation of PAs. The problems of this field were also discussed, including the nature of the final "enzyme" which catalyzes the polymerization reaction of PAs and the possible mechanism of how the elementary units of flavanols are assembled in vivo.
引用
收藏
页码：2674 / 2703
页数：30
相关论文
共 176 条
[1]   Identification and biochemical characterization of mutants in the proanthocyanidin pathway in Arabidopsis [J].
Abrahams, S ;
Tanner, GJ ;
Larkin, PJ ;
Ashton, AR .
PLANT PHYSIOLOGY, 2002, 130 (02) :561-576
[2]  
ACHMADI S, 1994, PHYTOCHEMISTRY, V35, P217
[3]   Four specific isogenes of the anthocyanin metabolic pathway are systematically co-expressed with the red colour of grape berries [J].
Ageorges, A ;
Fernandez, L ;
Vialet, S ;
Merdinoglu, D ;
Terrier, N ;
Romieu, C .
PLANT SCIENCE, 2006, 170 (02) :372-383
[4]   Cytochrome P450s in flavonoid metabolism [J].
Ayabe S.-I. ;
Akashi T. .
Phytochemistry Reviews, 2006, 5 (2-3) :271-282
[5]   Allelopathy and exotic plant invasion: From molecules and genes to species interactions [J].
Bais, HP ;
Vepachedu, R ;
Gilroy, S ;
Callaway, RM ;
Vivanco, JM .
SCIENCE, 2003, 301 (5638) :1377-1380
[6]   TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana [J].
Baudry, A ;
Heim, MA ;
Dubreucq, B ;
Caboche, M ;
Weisshaar, B ;
Lepiniec, L .
PLANT JOURNAL, 2004, 39 (03) :366-380
[7]   TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana [J].
Baudry, Antoine ;
Caboche, Michel ;
Lepiniec, Loic .
PLANT JOURNAL, 2006, 46 (05) :768-779
[8]   Expression of an Antirrhinum dihydroflavonol reductase gene results in changes in condensed tannin structure and accumulation in root cultures of Lotus corniculatus (bird's foot trefoil) [J].
Bavage, AD ;
Davies, IG ;
Robbins, MP ;
Morris, P .
PLANT MOLECULAR BIOLOGY, 1997, 35 (04) :443-458
[9]   A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana [J].
Baxter, IR ;
Young, JC ;
Armstrong, G ;
Foster, N ;
Bogenschutz, N ;
Cordova, T ;
Peer, WA ;
Hazen, SP ;
Murphy, AS ;
Harper, JF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (07) :2649-2654
[10]  
BEDNAR RA, 1988, J BIOL CHEM, V263, P9582
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