Regenerative Medicine: Injectable Cell-Based Therapeutics and Approved Products

被引:13
作者
Golchin, Ali [1 ]
Shams, Forough [2 ]
Kangari, Parisa [3 ]
Azari, Arezoo [4 ]
Hosseinzadeh, Simzar [4 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Student Res Comm, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Biotechnol, Tehran, Iran
[3] Shiraz Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Shiraz, Iran
[4] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran, Iran
来源
CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 7: STEM CELLS AND THERAPY: EMERGING APPROACHES | 2020年 / 1237卷
关键词
Cellular therapy; Injectable product; Regenerative medicine; MESENCHYMAL STEM-CELLS; CHIMERIC ANTIGEN RECEPTOR; DELIVERY; THERAPY; MIGRATION; HYDROGELS;
D O I
10.1007/5584_2019_412
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Cellular-based therapies have drawn a great deal of attention thanks to their regenerative medicine approaches to treat incurable diseases and specific injuries. In this regard, injectable cell delivery systems could actualize the therapeutically beneficial outcomes of cell-based therapeutic products. These systems have found considerable clinical uses. Hence, the recent studies have focused on developing injectable bio-constructs to protect transplanted cells during delivery and stimulating endogenous regeneration through interactions of these cells and host tissue. This paper introduces a framework, as a general concept, to improve cell delivery systems for cell-based therapeutic products. Studies on stable injectable carriers can enhance cell homing, proliferation, viability, dressing of irregular shape of target sites, and subsequently support transplanted cell functionality. However, more studies should be conducted on new technologies for the injectable cell-based product for cell delivery and the clinical applications.
引用
收藏
页码:75 / 95
页数:21
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