Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens

被引：70

作者：

Takasaki, M

Tokuda, H

Nishino, H

Konoshima, T ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[2] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6020841, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 07期

关键词：

D O I：

10.1021/np990033w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sixteen compounds (1-16) isolated from the flowering whole plant of Ajuga decumbens have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induction by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), as a primary screening test for antitumor-promoters (potential cancer chemopreventive agents). Five compounds (6, 9, and 12-14) showed strong inhibitory effects on EBV-EA induction. Of these active compounds, two major constituents of this plant, cyasterone (6) and 8-acetylharpagide (13), showed potent antitumor-promoting activities on a mouse-skin in vivo two-stage carcinogenesis procedure, using 7,12-dimethylbenz[a]anthracene as initiator and TPA as promoter. Further, compound 13 also exhibited potent chemopreventive activity in a mouse pulmonary tumor model.

引用

页码：972 / 975

页数：4

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