Prenylated phloroglucinol derivatives from Hypericum sampsonii

被引：28

作者：

Xin, Wen-bo ^{[1
]}

Man, Xiao-hua ^{[2
]}

Zheng, Cheng-jian ^{[1
]}

Jia, Min ^{[1
]}

Jiang, Yi-ping ^{[1
]}

Zhao, Xiang-xiang ^{[1
]}

Jin, Gui-lin ^{[1
]}

Mao, Zhu-jun

Huang, Hai-qiu ^{[3
]}

Qin, Lu-ping ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China

[3] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA

来源：

FITOTERAPIA | 2012年 / 83卷 / 08期

关键词：

Hypericum sampsonii; Phloroglucinol; Sampsonol; Cytotoxicity; Anti-inflammatory activity; BENZOYLPHLOROGLUCINOL DERIVATIVES; BENZOPHENONE DERIVATIVES; UNIQUE FAMILY; XANTHONES;

D O I：

10.1016/j.fitote.2012.08.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new acylphloroglucinol derivatives, sampsonols A-F (1-6), were isolated from the petroleum ether extract of the aerial parts of Hypericum sampsonii. The structures and relative configurations of sampsonols A-F were elucidated by extensive spectroscopic analyses. All these compounds were tested for their in vitro cytotoxic and anti-inflammatory activities. Sampsonols A and B (1 and 2) showed significant cytotoxicity against four human tumor cell lines with IC50 values in the range of 13-28 mu M, whereas sampsonols C and F (3 and 6) showed potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 27.3 and 293 mu M, respectively. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1540 / 1547

页数：8

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