The molecular profile of microglia under the influence of glioma

被引：274

作者：

Li, Wei ^{[1
]}

Graeber, Manuel B. ^{[1
]}

机构：

[1] Univ Sydney, Barnet Cropper Chair Brain Tumor Res, Brain & Mind Res Inst, Brain Tumor Res Labs, Sydney, NSW 2050, Australia

来源：

NEURO-ONCOLOGY | 2012年 / 14卷 / 08期

关键词：

alternatively activated macrophage; glioma-infiltrating microglia; macrophages; immunosuppression; synthetic biology; tumor-associated macrophages; ENDOTHELIAL-GROWTH-FACTOR; COLONY-STIMULATING FACTOR; CENTRAL-NERVOUS-SYSTEM; MHC CLASS-II; HUMAN GLIOBLASTOMA-MULTIFORME; TUMOR-ASSOCIATED MACROPHAGES; FACTOR SCATTER FACTOR; HUMAN-BRAIN TUMORS; TGF-BETA ISOFORMS; ADAPTIVE IMMUNE-RESPONSES;

D O I：

10.1093/neuonc/nos116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Microglia, which contribute substantially to the tumor mass of glioblastoma, have been shown to play an important role in glioma growth and invasion. While a large number of experimental studies on functional attributes of microglia in glioma provide evidence for their tumor-supporting roles, there also exist hints in support of their anti-tumor properties. Microglial activities during glioma progression seem multifaceted. They have been attributed to the receptors expressed on the microglia surface, to glioma-derived molecules that have an effect on microglia, and to the molecules released by microglia in response to their environment under glioma control, which can have autocrine effects. In this paper, the microglia and glioma literature is reviewed. We provide a synopsis of the molecular profile of microglia under the influence of glioma in order to help establish a rational basis for their potential therapeutic use. The ability of microglia precursors to cross the bloodbrain barrier makes them an attractive target for the development of novel cell-based treatments of malignant glioma.

引用

页码：958 / 978

页数：21

共 298 条

[11] Expression of Fas ligand by microglia: possible role in glioma immune evasion [J].