Effect of BRAF/MEK Inhibition on Epithelioid Glioblastoma with BRAFV600E Mutation: a Case Report and Review of the Literature

被引：4

作者：

Li, Yan ^{[1
]}

Yang, Shoubo ^{[2
]}

Hao, Chengcheng ^{[1
]}

Chen, Janxin ^{[1
]}

Li, Shan ^{[1
]}

Kang, Zhuang ^{[2
]}

Kang, Xun ^{[2
]}

Zhang, Hongmei ^{[1
]}

Li, Wenbin ^{[2
]}

机构：

[1] Capital Med Univ, Beijing Shijitan Hosp, Dept Glioma, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Tiantan Hosp, Neurosurg Ctr, Dept Neurooncol, Beijing, Peoples R China

来源：

CLINICAL LABORATORY | 2020年 / 66卷 / 08期

关键词：

epithelioid glioblastoma; BRAFV600E mutation; vemurafenib; dabrafenib; trametinib; CENTRAL-NERVOUS-SYSTEM; MELANOMA; VEMURAFENIB; DABRAFENIB; SURVIVAL; THERAPY;

D O I：

10.7754/Clin.Lab.2020.191134

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: To explore the effect of BRAF inhibitor on epithelioid glioblastoma (Ep-GBM) with BRAFV600E mutation. Methods: A patient of Ep-GBM with BRAFV600E mutation underwent BRAF inhibition therapy. The rationale behind combined BRAF and MEK inhibition in Ep-GBM was reviewed. Results: Vemurafenib can initially inhibit the progression of Ep-GBM with BRAFV600E mutation. However, the tumor may become resistant to vemurafenib and then progress. Conclusions: BRAF inhibition therapy can inhibit the progression of Ep-GBM with BRAFV600E mutation, but the subsequent resistance development leads to a poor outcome.

引用

页码：1629 / 1633

页数：5

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