Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010

被引：47

作者：

Wang, Yuan-Hong ^{[1
]}

Zhou, Dun-Jin ^{[1
]}

Zhou, Xuan ^{[1
]}

Yang, Ting ^{[2
]}

Ghosh, Souvik ^{[3
]}

Pang, Bei-Bei ^{[1
]}

Peng, Jin-Song ^{[1
]}

Liu, Man-Qing ^{[1
]}

Hu, Quan ^{[1
]}

Kobayashi, Nobumichi ^{[3
]}

机构：

[1] Wuhan Ctr Dis Prevent & Control, Virol Sect, Wuhan 430015, Hubei, Peoples R China

[2] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China

[3] Sapporo Med Univ, Sch Med, Dept Hyg, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

来源：

ARCHIVES OF VIROLOGY | 2012年 / 157卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Norovirus; Children; Adults; Genotype; Recombination; SPORADIC GASTROENTERITIS; GENETIC-ANALYSIS; GII.4; NOROVIRUS; INFECTIONS; EMERGENCE; DIARRHEA; STRAINS; VARIANT; RECOMBINATION; DIVERSITY;

D O I：

10.1007/s00705-012-1437-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To study epidemiological features and genetic characteristics of noroviruses in children and adults with acute gastroenteritis, fecal specimens were collected in three hospitals from Jan. 2007 to May 2010 in Wuhan, China. Noroviruses were detected in 25.9 % (286/1103) and 24.6 % (202/822) of the specimens from children and adults, respectively, with genogroup II (GII) being predominant (99.2 %). The most frequent genotype among GII strains was GII.4 (2006b variant) (77.3 %) (72.0 % in children and 87.9 % in adults), followed by GII.3 (15.0 %) and GII.6 (3.4 %). Potential recombinant genotypes (polymerase/capsid) were detected in 51 GII strains (15.9 %), including the most frequent type, GII.12/GII.3 (28 strains), and GII.16/GII.2, detected for the first time in China, which were found in only children. The results indicated that genetically similar noroviruses were circulating among children and adults as a cause of gastroenteritis, except for some recombinant genotypes.

引用

页码：2417 / 2424

页数：8

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