Synthesis and Antibacterial Activity of Calycanthaceous Alkaloid Derivatives

被引：11
作者：
Zheng, Shaojun [1 ,2 ,3 ]
Gu, Yongdong [1 ]
Zhu, Rui [1 ]
Li, Longbo [3 ]
Bai, Hongjin [2 ]
Zhang, Jiwen [3 ]
机构：
[1] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212003, Jiangsu, Peoples R China
[2] Tarim Univ, Key Lab Protect & Utilizat Biol Resources Tarim B, Coll Life Sci, Alar Xinjiang 843300, Peoples R China
[3] Key Lab Bot Pesticide R&D Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2018年 / 54卷 / 01期
基金：
中国国家自然科学基金;
关键词：
calycanthaceous alkaloids; synthesis; antibacterial activity; agrochemicals; tryptophan; CHIMONANTHUS-PRAECOX; ANTIFUNGAL ACTIVITY; INSECTICIDAL ACTIVITIES; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; CELANGULIN-V; (+/-)-FOLICANTHINE; PODOPHYLLOTOXIN; BIOSYNTHESIS; ANALOGS;
D O I：
10.1007/s10600-018-2274-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 45 calycanthaceous alkaloid derivatives with the tetrahydropyrroloindole core structure was synthesized from tryptophan in good yields. The synthesized compounds were evaluated against five strains of bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coil, Ralstonia solanacearum, and Pseudomonas aeruginosa). The bioassays indicated that among the synthesized compounds, compounds b3 and b4 exhibited a high degree of activity towards Gram positive B. subtilis. Compounds a14 and a18 displayed a high degree of activity towards R. solanacearum. These results will pave the way for further design, structural modification, and development of calycanthaceous alkaloids as antibacterial agents.
引用
收藏
页码：127 / 130
页数：4
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