Versatile synthesis of N,S-heterocycles containing the antipyrine moiety

被引:16
作者
Abdel-Latif, E [1 ]
机构
[1] Univ Mansoura, Fac Sci, Dept Chem, Mansoura 35516, Egypt
关键词
antipyrine; sulfur nucleophiles; aminothiazole; ball-milling; azo coupling; phenyl isothiocyanate; ketene N; S-acetal; dihydrothiazole; thiazolidin-5-one;
D O I
10.1080/104265090969054
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A series of novel sulfide derivatives of expected biological activity were synthesized via the reaction of 4-(chloroacetyl) antipyrine (1) with several sulfur nucleophiles. The quantitatively available 2-aminothiazole derivatives 10 and 11 were coupled with pyrazolopyridinyl and aromatic diazonium salts to furnish a new series of the corresponding pyrazolopyridinylazo and arylazo-thiazole dyes 12 and 13. The reaction of 4-(cyanoacetyl) antipyrine (14) with phenyl isothiocyanate afforded the nonisolable adduct 15, which was used as a precursor for the synthesis of polyfunctionally substituted ketene N,S-acetal, dihydrothiazole, and thiazolidinone ring systems.
引用
收藏
页码:125 / 139
页数:15
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