Replication licensing and cancer - a fatal entanglement?

被引：174
作者：
Blow, J. Julian [1 ]
Gillespie, Peter J. [1 ]
机构：
[1] Univ Dundee, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 10期
关键词：
D O I：
10.1038/nrc2500
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
引用
收藏
页码：799 / 806
页数：8
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