High-performance liquid chromatographic assay for the simultaneous determination of sulfadoxine and pyrimethamine from whole blood dried onto filter paper

被引：41

作者：

Green, MD ^{[1
]}

Mount, DL ^{[1
]}

Nettey, H ^{[1
]}

机构：

[1] CDCP, Div Parasit Dis, Natl Ctr Infect Dis, Publ Hlth Serv, Atlanta, GA 30333 USA

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2002年 / 767卷 / 01期

关键词：

sulfadoxine; pyrimethamine;

D O I：

10.1016/S0378-4347(01)00547-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method using solid-phase extraction and high-performance liquid chromatography is evaluated for the simultaneous determination of sulfadoxine and pyrimethamine from 0.1 ml of whole blood dried onto filter paper. Extraction recoveries are about 60% for both drugs. The coefficient of variation for intra-assay precision, inter-assay precision and accuracy is less than 10% for sulfadoxine (10-100 mug/ml) and pyrimethamine (1-10 mug/ml). Published by Elsevier Science B.V.

引用

页码：159 / 162

页数：4

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