Neuroprotective activities of natural products from marine macroalgae during 1999-2015

被引：42
作者：
Alghazwi, Mousa [1 ,2 ,3 ]
Kan, Yen Qi [1 ,2 ]
Zhang, Wei [1 ,2 ]
Gai, Wei Ping [4 ]
Garson, Mary J. [5 ]
Smid, Scott [6 ]
机构：
[1] Flinders Univ S Australia, Flinders Ctr Marine Bioprod Dev CMBD, GPO Box 2100, Adelaide, SA 5001, Australia
[2] Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, GPO Box 2100, Adelaide, SA 5001, Australia
[3] Minist Higher Educ Saudi Arabia, King Faisal Hosp St, Riyadh 11153, Saudi Arabia
[4] Flinders Univ S Australia, Sch Med, Dept Physiol, Flinders Med Ctr, GPO Box 2100, Adelaide, SA 5001, Australia
[5] Univ Queensland, Fac Sci, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia
[6] Univ Adelaide, Sch Med, Discipline Pharmacol, Fac Hlth Sci, Adelaide, SA, Australia
来源：
JOURNAL OF APPLIED PHYCOLOGY | 2016年 / 28卷 / 06期
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Macroalgae; Seaweed; Neuroprotective activity; Natural products; Neurodegenerative diseases; CHOLINESTERASE-INHIBITORY-ACTIVITY; H2O2-INDUCED OXIDATIVE STRESS; ALZHEIMERS-DISEASE THERAPY; PROMOTES NEURITE OUTGROWTH; ALGA CAULERPA-RACEMOSA; NERVE GROWTH-FACTOR; INDUCED CELL-DAMAGE; BROWN-ALGA; ECKLONIA-CAVA; PC12; CELLS;
D O I：
10.1007/s10811-016-0908-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This review focuses on macroalgae-derived compounds with neuroprotective activity that may provide lead compounds for the prevention and treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Coverage is provided from 1999 to 2015. A total of 99 pure compounds have been reported. The main in vitro bioactivities of these compounds include inhibition of beta amyloid protein (A beta), inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), reduction in oxidative stress, anti-inflammatory activity, inhibition of kinases, enhancement of neurite outgrowth and the reduction in dopaminergic neurotoxicity. The majority of these bioactive compounds are derived from Phaeophyceae (57.6 %), followed by Rhodophyta (28.3 %) and Chlorophyta (14.1 %). This review presents valuable knowledge on macroalgae-derived compounds and their known pathways of neuroprotection to further explore the potential of these compounds in preventing and treating neurodegenerative diseases.
引用
收藏
页码：3599 / 3616
页数：18
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