A step forward in understanding glomerular filtration

被引：6

作者：

Moeller, Marcus J. ^{[1
]}

Chia-Gil, Arnaldo ^{[1
]}

机构：

[1] RWTH Aachen Univ Clin, Dept Nephrol & Clin Immunol, Aachen, Germany

来源：

NATURE REVIEWS NEPHROLOGY | 2020年 / 16卷 / 08期

关键词：

ALBUMIN; BARRIER;

D O I：

10.1038/s41581-020-0313-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanism underlying glomerular filtration barrier selectivity has not been resolved. A new study that reports an inverse correlation between slit diaphragm density and proteinuria in a genetic mouse model of focal segmental glomerulosclerosis suggests that podocytes function to compress the glomerular basement membrane (GBM) and that failure of this process results in GBM stretching and increased permeability.

引用

页码：431 / 432

页数：2

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