A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy

被引：62

作者：

Alibhai, Shabbir M. H. ^{[1
,2
,3
,4
]}

O'Neill, Sara ^{[1
]}

Fisher-Schlombs, Karla ^{[1
]}

Breunis, Henriette ^{[1
]}

Brandwein, Joseph M. ^{[1
,3
]}

Timilshina, Narhari ^{[1
]}

Tomlinson, George A. ^{[1
,5
]}

Klepin, Heidi D. ^{[6
]}

Culos-Reed, S. Nicole ^{[7
,8
]}

机构：

[1] Univ Hlth Network, Dept Med, Toronto, ON M5G 2C4, Canada

[2] Toronto Rehabil Inst, Geriatr Program, Toronto, ON, Canada

[3] Univ Toronto, Dept Med, Toronto, ON, Canada

[4] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[5] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON, Canada

[6] Wake Forest Univ, Dept Hematol & Oncol, Winston Salem, NC 27109 USA

[7] Univ Calgary, Dept Kinesiol, Calgary, AB, Canada

[8] Tom Baker Canc Clin, Dept Psychosocial Resources, Calgary, AB, Canada

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 10期

关键词：

Acute myeloid leukemia; Chemotherapy; Exercise; Pilot study; Quality of life; Cancer-related fatigue; Elderly; Physical fitness; QUALITY-OF-LIFE; ACUTE MYELOGENOUS LEUKEMIA; FUNCTIONAL ASSESSMENT; PHYSICAL-ACTIVITY; CANCER SURVIVORS; HOSPITAL ANXIETY; OLDER-ADULTS; FATIGUE; THERAPY; INTERVENTIONS;

D O I：

10.1016/j.leukres.2012.05.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with acute myeloid leukemia (AML) receiving induction chemotherapy (IC) were enrolled in a supervised exercise intervention to determine safety, feasibility, and efficacy. Physical fitness measures, quality of life (QOL) and fatigue were assessed using standardized measures at baseline, post-induction, and post first consolidation. Retention was excellent, the intervention was safe, and efficacy estimates suggested benefits in physical fitness and QOL outcomes. Exercise is a safe, promising intervention for improving fitness and QOL in this patient population. These results provide a foundation for a randomized trial to better understand the impact of exercise during IC on clinically important outcomes. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1255 / 1261

页数：7

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