Prognostic value of computed tomography-based volumetric body composition analysis in patients with head and neck cancer: Feasibility study

被引：12
作者：
Choi, Yangsean [1 ]
Ahn, Kook-Jin [1 ]
Jang, Jinhee [1 ]
Shin, Na-Young [1 ]
Jung, So-Lyung [2 ]
Kim, Bum-soo [1 ]
Kim, Min-Sik [3 ]
Kim, Yeon-Sil [4 ]
机构：
[1] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Radiol, 222 Banpo Daero, Seoul 06591, South Korea
[2] Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Radiol, Seoul, South Korea
[3] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea
[4] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Radiat Oncol, Seoul, South Korea
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 09期
关键词：
body composition; head and neck cancer; radiotherapy; risk assessment; sarcopenia; survival analysis; WEIGHT-LOSS; SARCOPENIC OBESITY; MASS INDEX; SURVIVAL; RADIOTHERAPY; LYMPHEDEMA; OUTCOMES; WOMEN;
D O I：
10.1002/hed.26310
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background This study aimed to evaluate whether computed tomography (CT)-based volumetric body composition analysis has prognostic value in head and neck cancer (HNC) patients. Methods This single-center retrospective study included 79 patients with HNC treated with definitive radiotherapy from March 2009 to December 2018. The patients were assessed for (a) weight-based variables and (b) pretreatment and posttreatment CT-based body composition variables. Overall survival (OS) and recurrence-free survival (RFS) analyses were conducted using Cox proportional hazards analyses. Results Depletion of cervical skeletal muscle volume on presentation was associated with poor OS (hazard ratio [HR] = 3.1; 95% CI = 1.2-7.8;P= .016). Low fat proportions before and after treatment were associated with poor OS (HR = 2.5-3.5; 95% CI = 1.3-9.3;P= .013-.026). In multivariate Cox analysis, increased posttreatment fat attenuation demonstrated the greatest prognostic value for both OS (HR = 4.7; 95% CI = 2.2-10.3;P < .001) and RFS (HR = 4.3; 95% CI = 2.0-9.5;P < .001). Conclusions CT-based body composition analysis has the potential for risk assessment in patients with HNC.
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收藏
页码：2614 / 2625
页数：12
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