Immunoadhesins: Principles and applications

被引：73

作者：

Chamow, SM ^{[1
]}

Ashkenazi, A ^{[1
]}

机构：

[1] GENENTECH INC,DEPT MOLEC ONCOL,S SAN FRANCISCO,CA 94080

来源：

TRENDS IN BIOTECHNOLOGY | 1996年 / 14卷 / 02期

关键词：

D O I：

10.1016/0167-7799(96)80921-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The prototypic immunoadhesin is an antibody-like molecule that fuses the Fc region of an immunoglobulin and the ligand-binding region of a receptor or adhesion molecule. In this article, we review some important structural and functional principles of immunoadhesins. In addition, we highlight some unique advantages of immunoadhesins as experimental tools in biology, as well as some of their exciting potential applications in medicine.

引用

页码：52 / 60

页数：9

共 95 条

[1]

ABBATE M, 1993, EUR J CELL BIOL, V61, P139

[2] CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].

ARUFFO, A ;

STAMENKOVIC, I ;

MELNICK, M ;

UNDERHILL, CB ;

SEED, B .

CELL, 1990, 61 (07) :1303-1313

[3] A SOLUBLE MULTIMERIC RECOMBINANT CD2 PROTEIN IDENTIFIES CD48 AS A LOW AFFINITY LIGAND FOR HUMAN CD2 - DIVERGENCE OF CD2 LIGANDS DURING THE EVOLUTION OF HUMANS AND MICE [J].

ARULANANDAM, ARN ;

MOINGEON, P ;

CONCINO, MF ;

RECNY, MA ;

KATO, K ;

YAGITA, H ;

KOYASU, S ;

REINHERZ, EL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (05) :1439-1450

[4] MAPPING THE CD4 BINDING-SITE FOR HUMAN-IMMUNODEFICIENCY-VIRUS BY ALANINE-SCANNING MUTAGENESIS [J].

ASHKENAZI, A ;

PRESTA, LG ;

MARSTERS, SA ;

CAMERATO, TR ;

ROSENTHAL, KA ;

FENDLY, BM ;

CAPON, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7150-7154

[5]

Ashkenazi A, 1993, Int Rev Immunol, V10, P219, DOI 10.3109/08830189309061697

[6] PROTECTION AGAINST ENDOTOXIC-SHOCK BY A TUMOR-NECROSIS-FACTOR RECEPTOR IMMUNOADHESIN [J].

ASHKENAZI, A ;

MARSTERS, SA ;

CAPON, DJ ;

CHAMOW, SM ;

FIGARI, IS ;

PENNICA, D ;

GOEDDEL, DV ;

PALLADINO, MA ;

SMITH, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) :10535-10539

[7]

Ashkenazi Avi, 1995, Methods (Orlando), V8, P104, DOI 10.1006/meth.1995.9996

[8] MOLECULAR CHARACTERIZATION OF MURINE AND HUMAN OX40/OX40 LIGAND SYSTEMS - IDENTIFICATION OF A HUMAN OX40 LIGAND AS THE HTLV-1-REGULATED PROTEIN GP34 [J].

BAUM, PR ;

GAYLE, RB ;

RAMSDELL, F ;

SRINIVASAN, S ;

SORENSEN, RA ;

WATSON, ML ;

SELDIN, MF ;

BAKER, E ;

SUTHERLAND, GR ;

CLIFFORD, KN ;

ALDERSON, MR ;

GOODWIN, RG ;

FANSLOW, WC .

EMBO JOURNAL, 1994, 13 (17) :3992-4001

[9] BINDING OF L-SELECTIN TO THE VASCULAR SIALOMUCIN CD34 [J].

BAUMHUETER, S ;

SINGER, MS ;

HENZEL, W ;

HEMMERICH, S ;

RENZ, M ;

ROSEN, SD ;

LASKY, LA .

SCIENCE, 1993, 262 (5132) :436-438

[10] GENERATION OF SOLUBLE INTERLEUKIN-1 RECEPTOR FROM AN IMMUNOADHESIN BY SPECIFIC CLEAVAGE [J].

BECK, JT ;

MARSTERS, SA ;

HARRIS, RJ ;

CARTER, P ;

ASHKENAZI, A ;

CHAMOW, SM .

MOLECULAR IMMUNOLOGY, 1994, 31 (17) :1335-1344

← 1 2 3 4 5 6 7 8 9 10 →