Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity

被引：47

作者：

Kato, A. ^{[1
]}

Yasuko, H. ^{[1
]}

Goto, H. ^{[2
]}

Hollinshead, J. ^{[3
]}

Nash, R. J. ^{[3
]}

Adachi, I. ^{[1
]}

机构：

[1] Toyama Univ, Dept Hosp Pharm, Toyama 9300194, Japan

[2] Inst Nat Med, Dept Kampo Diagnost, Toyama 9300194, Japan

[3] Inst Grassland & Environm Res, Aberystwyth SY23 3EB, Ceredigion, Wales

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 2-3期

关键词：

Evodia rutaecarpa; Aldose reductase; Rhetsinine; Diabetic complications; POLYOL PATHWAY; DIABETIC NEUROPATHY; CELL SORBITOL; FLAVONOIDS; SORBINIL; RATS; RETINOPATHY; MECHANISMS; INDICATOR;

D O I：

10.1016/j.phymed.2007.04.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine. The hot water extract from the E. rutaecarpa was subjected to distribution or gel filtration chromatography to give an active compound, N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one (rhetsinine). It inhibited aldose reductase with IC(50) values of 24.1 mu M. Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100 mu M. These results suggested that the E rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications. (C) 2007 Elsevier GmbH. All rights reserved.

引用

页码：258 / 261

页数：4

共 25 条

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