Mouse Models of Pancreatic Ductal Adenocarcinoma

被引：10

作者：

Ponz-Sarvise, Mariano ^{[1
]}

Tuveson, David A. ^{[1
,2
]}

Yu, Kenneth H. ^{[1
,2
,3
]}

机构：

[1] Cold Spring Harbor Lab, Canc Biol, Cold Spring Harbor, NY 11724 USA

[2] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[3] Cornell Univ, Weill Med Coll, New York, NY 10065 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 04期

关键词：

Genetic engineered mouse models; Pancreatic cancer; Kras; Therapeutics; Models of cancer; SCID MICE; IN-VITRO; K-RAS; CANCER; TUMOR; CELLS; HYALURONAN; KRAS; CHEMOTHERAPY; PROGRESSION;

D O I：

10.1016/j.hoc.2015.04.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Only 10% to 15% of patients with pancreatic ductal adenocarcinoma (PDAC) are candidates for potentially curative surgery due to the location or spread of disease at the time of diagnosis. Despite rapid progress in the understanding of the molecular mechanisms underlying PDAC, translation to effective therapies has been modest at best. One of the key tools available for studying biology and developing more effective therapeutics is the laboratory mouse, mus musculus. This article explores new and innovative approaches to mouse modeling and how these approaches can be utilized to move the field forward.

引用

页码：609 / +

页数：10

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