Preparation, Toxicity, and Anti-Inflammatory Activity of Complexes of Uracil Derivatives with Polyfunctional Acids

被引：3

作者：

Zimin, Yu. S. ^{[1
]}

Borisova, N. S. ^{[1
]}

Timerbaeva, G. R. ^{[2
]}

Gimadieva, A. R. ^{[3
]}

Mustafin, A. G. ^{[1
,3
]}

机构：

[1] Bashkir State Univ, Ufa 452750, Bashkortostan, Russia

[2] Branch Ufa State Aviat Tech Univ, Tuimazy 452750, Bashkortostan, Russia

[3] Russian Acad Sci, Ufa Sci Ctr, Inst Chem, Ufa 450054, Bashkortostan, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 50卷 / 10期

关键词：

uracil derivatives; polyfunctional acids; complexation; toxicity; anti-inflammatory activity;

D O I：

10.1007/s11094-017-1507-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil molecule for each carboxylic acid of the polyfunctional acid. Synthetic methods for these complexes were developed based on the results. Their toxicity and anti-inflammatory activity were studied. It was established that complexes of 6-methyluracil with the oxidized fraction of citrus pectin and of 5-hydroxy-6-methyluracil with 5-aminosalicylic acid possessed low toxicity and high anti-inflammatory activity.

引用

页码：649 / 653

页数：5

共 29 条

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