Recognition of cytosolic DNA by cGAS and other STING-dependent sensors

被引：95

作者：

Bhat, Numana ^{[1
]}

Fitzgerald, Katherine A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol,Program Innate Immun, Worcester, MA 01605 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2014年 / 44卷 / 03期

关键词：

Immune regulation; Molecular biology; Molecular immunology; CYCLIC GMP-AMP; INNATE IMMUNE SENSOR; NUCLEIC-ACIDS; IFI16; ACTIVATION; INFECTION; INFLAMMASOME; RECEPTORS; RESPONSES; ADAPTER;

D O I：

10.1002/eji.201344127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting the host to the presence of microbial infection. In response to the detection of cytoplasmic DNA, the immune system mounts a programed response that involves the transcription of anti-viral genes such as type I interferons and production of inflammatory cytokines such as IL-1. The recent discovery of the cGAS-cGAMP second messenger pathway as well as IFI16 and additional sensors collectively provide critical insights into the molecular basis behind the sensing of cytoplasmic DNA. The insights obtained from these important discoveries could unveil new avenues to understand host-immunity, improve vaccine adjuvancy, and allow development of new treatments for inflammatory diseases associated with abberrant sensing of DNA.

引用

页码：634 / 640

页数：7

共 62 条

[21] TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines [J].

Ishii, Ken J. ;

Kawagoe, Tatsukata ;

Koyama, Shohei ;

Matsui, Kosuke ;

Kumar, Himanshu ;

Kawai, Taro ;

Uematsu, Satoshi ;

Takeuchi, Osamu ;

Takeshita, Fumihiko ;

Coban, Cevayir ;

Akira, Shizuo .

NATURE, 2008, 451 (7179) :725-U6

[22] A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA [J].

Ishii, KJ ;

Coban, C ;

Kato, H ;

Takahashi, K ;

Torii, Y ;

Takeshita, F ;

Ludwig, H ;

Sutter, G ;

Suzuki, K ;

Hemmi, H ;

Sato, S ;

Yamamoto, M ;

Uematsu, S ;

Kawai, T ;

Takeuchi, O ;

Akira, S .

NATURE IMMUNOLOGY, 2006, 7 (01) :40-48

[23] Innate immune recognition of nucleic acids: Beyond toll-like receptors [J].

Ishii, KJ ;

Akira, S .

INTERNATIONAL JOURNAL OF CANCER, 2005, 117 (04) :517-523

[24] STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling [J].

Ishikawa, Hiroki ;

Barber, Glen N. .

NATURE, 2008, 455 (7213) :674-U74

[25] STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity [J].

Ishikawa, Hiroki ;

Ma, Zhe ;

Barber, Glen N. .

NATURE, 2009, 461 (7265) :788-U40

[26] MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals [J].

Jin, Lei ;

Waterman, Paul M. ;

Jonscher, Karen R. ;

Short, Cindy M. ;

Reisdorph, Nichole A. ;

Cambier, John C. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (16) :5014-5026

[27] Structures of the HIN Domain: DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor [J].

Jin, Tengchuan ;

Perry, Andrew ;

Jiang, Jiansheng ;

Smith, Patrick ;

Curry, James A. ;

Unterholzner, Leonie ;

Jiang, Zhaozhao ;

Horvath, Gabor ;

Rathinam, Vijay A. ;

Johnstone, Ricky W. ;

Hornung, Veit ;

Latz, Eicke ;

Bowie, Andrew G. ;

Fitzgerald, Katherine A. ;

Xiao, T. Sam .

IMMUNITY, 2012, 36 (04) :561-571

[28] Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity [J].

Kawasaki, Takumi ;

Kawai, Taro ;

Akira, Shizuo .

IMMUNOLOGICAL REVIEWS, 2011, 243 :61-73

[29] IFI16 as a negative regulator in the regulation of p53 and p21Waf1 [J].

Kwak, JC ;

Ongusaha, PP ;

Ouchi, T ;

Lee, SW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :40899-40904

[30] The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells [J].

Lahaye, Xavier ;

Satoh, Takeshi ;

Gentili, Matteo ;

Cerboni, Silvia ;

Conrad, Cecile ;

Hurbain, Ilse ;

El Marjou, Ahmed ;

Lacabaratz, Christine ;

Lelievre, Jean-Daniel ;

Manel, Nicolas .

IMMUNITY, 2013, 39 (06) :1132-1142

← 1 2 3 4 5 6 7 →