Recognition of cytosolic DNA by cGAS and other STING-dependent sensors

被引：92

作者：

Bhat, Numana ^{[1
]}

Fitzgerald, Katherine A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol,Program Innate Immun, Worcester, MA 01605 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2014年 / 44卷 / 03期

关键词：

Immune regulation; Molecular biology; Molecular immunology; CYCLIC GMP-AMP; INNATE IMMUNE SENSOR; NUCLEIC-ACIDS; IFI16; ACTIVATION; INFECTION; INFLAMMASOME; RECEPTORS; RESPONSES; ADAPTER;

D O I：

10.1002/eji.201344127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting the host to the presence of microbial infection. In response to the detection of cytoplasmic DNA, the immune system mounts a programed response that involves the transcription of anti-viral genes such as type I interferons and production of inflammatory cytokines such as IL-1. The recent discovery of the cGAS-cGAMP second messenger pathway as well as IFI16 and additional sensors collectively provide critical insights into the molecular basis behind the sensing of cytoplasmic DNA. The insights obtained from these important discoveries could unveil new avenues to understand host-immunity, improve vaccine adjuvancy, and allow development of new treatments for inflammatory diseases associated with abberrant sensing of DNA.

引用

页码：634 / 640

页数：7

共 62 条

[1] Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP [J].

Ablasser, Andrea ;

Schmid-Burgk, Jonathan L. ;

Hemmerling, Inga ;

Horvath, Gabor L. ;

Schmidt, Tobias ;

Latz, Eicke ;

Hornung, Veit .

NATURE, 2013, 503 (7477) :530-+

[2] cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING [J].

Ablasser, Andrea ;

Goldeck, Marion ;

Cavlar, Taner ;

Deimling, Tobias ;

Witte, Gregor ;

Roehl, Ingo ;

Hopfner, Karl-Peter ;

Ludwig, Janos ;

Hornung, Veit .

NATURE, 2013, 498 (7454) :380-+

[3] Molecular Basis of DNA Recognition in the Immune System [J].

Atianand, Maninjay K. ;

Fitzgerald, Katherine A. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (05) :1911-1918

[4] Extensive evolutionary and functional diversity among mammalian AIM2-like receptors [J].

Brunette, Rebecca L. ;

Young, Janet M. ;

Whitley, Deborah G. ;

Brodsky, Igor E. ;

Malik, Harmit S. ;

Stetson, Daniel B. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (11) :1969-1983

[5] An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome [J].

Buerckstuemmer, Tilmann ;

Baumann, Christoph ;

Blueml, Stephan ;

Dixit, Evelyn ;

Duernberger, Gerhard ;

Jahn, Hannah ;

Planyavsky, Melanie ;

Bilban, Martin ;

Colinge, Jacques ;

Bennett, Keiryn L. ;

Superti-Furga, Giulio .

NATURE IMMUNOLOGY, 2009, 10 (03) :266-272

[6] STING is a direct innate immune sensor of cyclic di-GMP [J].

Burdette, Dara L. ;

Monroe, Kathryn M. ;

Sotelo-Troha, Katia ;

Iwig, Jeff S. ;

Eckert, Barbara ;

Hyodo, Mamoru ;

Hayakawa, Yoshihiro ;

Vance, Russell E. .

NATURE, 2011, 478 (7370) :515-U111

[7] Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity [J].

Chen, Huihui ;

Sun, Hui ;

You, Fuping ;

Sun, Wenxiang ;

Zhou, Xiang ;

Chen, Lu ;

Yang, Jing ;

Wang, Yutao ;

Tang, Hong ;

Guan, Yukun ;

Xia, Weiwei ;

Gu, Jun ;

Ishikawa, Hiroki ;

Gutman, Delia ;

Barber, Glen ;

Qin, Zhihai ;

Jiang, Zhengfan .

CELL, 2011, 147 (02) :436-446

[8] Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16 [J].

Conrady, C. D. ;

Zheng, M. ;

Fitzgerald, K. A. ;

Liu, C. ;

Carr, D. J. J. .

MUCOSAL IMMUNOLOGY, 2012, 5 (02) :173-183

[9] Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus [J].

Crow, Yanick J. ;

Hayward, Bruce E. ;

Parmar, Rekha ;

Robins, Peter ;

Leitch, Andrea ;

Ali, Manir ;

Black, Deborah N. ;

van Bokhoven, Hans ;

Brunner, Han G. ;

Hamel, Ben C. ;

Corry, Peter C. ;

Cowan, Frances M. ;

Frints, Suzanne G. ;

Klepper, Joerg ;

Livingston, John H. ;

Lynch, Sally Ann ;

Massey, Roger F. ;

Meritet, Jean Francois ;

Michaud, Jacques L. ;

Ponsot, Gerard ;

Voit, Thomas ;

Lebon, Pierre ;

Bonthron, David T. ;

Jackson, Andrew P. ;

Barnes, Deborah E. ;

Lindahl, Tomas .

NATURE GENETICS, 2006, 38 (08) :917-920

[10] New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease [J].

De Nardo, Dominic ;

De Nardo, Christine M. ;

Latz, Eicke .

AMERICAN JOURNAL OF PATHOLOGY, 2014, 184 (01) :42-54

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