Response inhibition and attention processing in 5-to 7-year-old children with and without symptoms of ADHD: An ERP study

被引:86
作者
Spronk, M. [1 ]
Jonkman, L. M. [1 ]
Kemner, C. [1 ,2 ]
机构
[1] Maastricht Univ, Fac Psychol, Dept Cognit Neurosci, NL-6200 MD Maastricht, Netherlands
[2] Univ Med Ctr, Dept Child & Adolescent Psychiat, Utrecht, Netherlands
关键词
Response inhibition; Attention; Event-related brain potentials; Attention-deficit hyperactivity disorder; Nogo-N2; Nogo-P3;
D O I
10.1016/j.clinph.2008.09.010
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Response inhibition and attention processing in 5- to 7-year-old children with or without symptoms of attention-deficit hyperactivity disorder (ADHD) were examined. Methods: Twelve children with ADHD symptoms and 15 control children performed a CPT-AX task. Behavioral Measures of inattention and impulsivity and ERP measures of conflict monitoring and inhibition (Nogo-N2 and Nogo-P3), cue-orientation and prestimulus target expectation (CUe-P2 and P3) and response preparation (CNV) were collected. Results: ADHD children detected fewer targets and had higher Inattention scores accompanied by reduced centro-parietal Cue- and Go-P3 activity. Occipital CNV amplitude was larger in ADHD children. At fronto-central leads, strong and comparable fronto-parietal Nogo-N2 effects were found in both groups, whereas the Nogo-P3 was only marginally significant in both groups. Conclusions: The attenuated Cue- and Go-P3 effects in the ADHD-symptom group are interpreted as early signs of delayed attention development, resulting in less preparation and less alertness to detect significant events. Whereas the Nogo-N2 effects were interpreted as signs of comparable levels of conflict processing in both groups, the small Nogo-P3 suggests that inhibitory processing is still immature at this age. Significance: The present Study shows that specific attention problems can already be detected in the behavior and brain activity of 5- to 7-year-old children with symptoms of ADHD performing a CPT-AX task, and might be better indicators for the risk of developing ADHD than impulsivity measures. (c) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All Fights reserved.
引用
收藏
页码:2738 / 2752
页数:15
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