Noradrenaline induces IPSCs in rat medial septal/diagonal band neurons: Involvement of septohippocampal GABAergic neurons

被引:42
作者
Alreja, M [1 ]
Liu, WM [1 ]
机构
[1] CONNECTICUT MENTAL HLTH CTR,ABRAHAM RIBICOFF RES FACIL,NEW HAVEN,CT 06508
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1996年 / 494卷 / 01期
关键词
D O I
10.1113/jphysiol.1996.sp021485
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. The physiological and pharmacological actions of noradrenaline (NA) on neurons of the medial septum and diagonal band of Broca (MSDB) were examined using extracellular, intracellular and whole-cell patch-clamp recordings in an in vitro rat brain slice preparation. 2. In current- and voltage-clamp recordings with KCl- or potassium gluconate-containing electrodes, bath-applied NA increased the number of tetrodoxin- and bicuculline-sensitise synaptic events in > 80 % of cholinergic- and GABA-type neurons tested. The NA-induced synaptic activity originated from GABAergic neurons located within the MSDB itself as a similar effect occurred in brain slices in which the MSDB had been surgically isolated from neighbouring structures. 3. In antidromic studies, NA dose-dependently increased firing in a subpopulation of septohippocampal neurons with fast conducting fibres (mean conduction velocity, 1.78 +/- 0.10 m s(-1); presumably GABAergic). The NH excitation was mimicked by the alpha(1)-agonist phenylephrine (PE) and blocked by the alpha(1)-antagonists prazosin and WB-4101, suggesting the presence of alpha(1)-receptors on septohippocampal GABAergic neurons. 4. Similarly, in whole-cell recordings in both cholinergic- and non-cholinergic-type MSDB neurons, prazosin blocked the effects of NE and PE mimicked the effects of NA by inducing IPSCs with a similar amplitude distribution. 5. Consistent with the above findings, GABA-type neurons that responded directly to NA and PE with a prazosin-sensitive inward current were found within the MSDB. 6. In conclusion, NA, via alpha(1)-adrenoceptors, excites MSDB septohippocampal GABAergic neurons and influences both septal and septohippocampal circuitry.
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收藏
页码:201 / 215
页数:15
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