Convenient syntheses of dihydropyrrolo[2′,1′:3,4]pyrazino- and dihydropyrrolo[2′,1′:3,4][1,4]diazepino-[2,1-α]isoindolones

被引：24
作者：
Katritzky, AR [1 ]
He, HY [1 ]
Jiang, R [1 ]
机构：
[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 15期
关键词：
D O I：
10.1016/S0040-4039(02)00350-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Dihydropyrrolo[2'.1':3,4]pyrazino[2.1-a]isoindolones 10a-10c were obtained in 76-81% yields by the reaction of 2-(1H-pyrrol-l-yl)ethylamine 8 with 2-formylbenzoic acids 9a, 9b or 22-acetylbenzoic acid 9c via N-acyliminium cation aromatic cyclizations. Similarly, dihydropyrrolo[2',1':3,4][1,4]diazepino[2.1-a]isoindolones 12a, 12b were prepared in one-pot reactions front 3-(1H-pyrrol-l-yl)propylamine 11 and 2-formylbenzoic acids 9a, 9b. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：2831 / 2833
页数：3
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