Mapping of type I loci from human chromosome 7 reveals segments of conserved synteny on pig chromosomes 3, 9, and 18

被引：18
作者：
Bruch, J
Rettenberger, G
Leeb, T
MeierEwert, S
Klett, C
Brenig, B
Hameister, H
机构：
[1] UNIV ULM,ABT MED GENET,D-89069 ULM,GERMANY
[2] UNIV GOTTINGEN,TIERARZTLICHES INST,D-3400 GOTTINGEN,GERMANY
[3] MAX PLANCK INST MOLEC GENET,D-1000 BERLIN,GERMANY
来源：
CYTOGENETICS AND CELL GENETICS | 1996年 / 73卷 / 03期
关键词：
ASSIGNMENT; MAMMALS; GENE;
D O I：
10.1159/000134331
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have mapped in the pig (Sus scrofa) the genes for zona pellucida glycoprotein 3 (ZP3), erythropoietin (EPO), and malate dehydrogenase 2 (MDH2) by somatic cell hybrid analysis in the pig genome. Previously, the gene for the T-cell receptor beta cluster (TCRB) was assigned to SSC 18 and that. for interleukin 6 (IL6) to SSC 9. However, statistical analysis of mapping data for ZP3, EPO, and MDH2 did not discriminate between SSC 9 and SSC 3. Porcine-specific PCR primers for ZP3 and IL6 were used to isolate probes from porcine YAC libraries. These two genes were mapped by FISH to porcine chromosome regions 3pter-->p15 (ZP3) and 9q14-->q15 (IL6). Comparative mapping considerations permit the tentative assignment of porcine EPO and MDH2 to 3pter-->p15.
引用
收藏
页码：164 / 167
页数：4
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