Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial Activity

被引：52

作者：

Li, Jing ^{[1
]}

Lv, Chang-Wei ^{[2
]}

Li, Xiao-Jun ^{[1
]}

Qu, Di ^{[3
]}

Hou, Zheng ^{[3
]}

Jia, Min ^{[3
]}

Luo, Xiao-Xing ^{[3
]}

Li, Xia ^{[4
]}

Li, Ming-Kai ^{[3
]}

机构：

[1] Xian Univ, Sch Chem Engn, Xian 710065, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Orthopaed, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Sch Pharm, Dept Pharmacol, Xian 710032, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

来源：

MOLECULES | 2015年 / 20卷 / 09期

基金：

中国国家自然科学基金;

关键词：

biscoumarins; dihydropyran; S; aureus; epidermidis; INTRAMOLECULAR HYDROGEN-BONDS; COUMARIN; PLANTS;

D O I：

10.3390/molecules200917469

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In an attempt to find a new class antibacterial agents, a series of biscoumarins (1-4) and dihydropyrans (5-13) were successfully prepared. The molecular structures of four representative compounds, that is, 4, 5, 8 and 12 were confirmed by single crystal X-ray diffraction study. These synthesized compounds were screened for their antibacterial activity in vitro against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), USA 300 (Los Angeles County clone, LAC), Staphylococcus epidermidis (S. epidermidis ATCC 14990), methicillin-resistant S. epidermidis (MRSE XJ 75284) and Escherichia coli (E. coli ATCC 25922). Additionally, there are two classical intramolecular O-H<bold>O hydrogen bonds </bold>(HBs) in biscoumarins 1-4 and the corresponding HB energies were further performed with the density functional theory (DFT) [B3LYP/6-31G*] method.

引用

页码：17469 / 17482

页数：14

共 23 条

[1] DENSITY-FUNCTIONAL THERMOCHEMISTRY .3. THE ROLE OF EXACT EXCHANGE [J].