Effects of Omeprazole on Iron Absorption: Preliminary Study

被引:8
作者
Tempel, Mila [1 ]
Chawla, Anupama [1 ]
Messina, Catherine [2 ]
Celiker, Mahmut Yasar [1 ]
机构
[1] Stony Brook Long Isl Childrens Hosp, Dept Pediat, Stony Brook, NY USA
[2] SUNY Stony Brook, Med Ctr, Dept Prevent Med, Stony Brook, NY 11794 USA
关键词
Iron; Omeprazole; PPI; Proton pump inhibitors; Anemia; DEFICIENCY ANEMIA; DIETARY IRON;
D O I
10.4274/tjh.2013.0042
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Increasing numbers of pediatric and adult patients are being treated with proton pump inhibitors (PPIs). PPIs are known to inhibit gastric acid secretion. Nonheme iron requires gastric acid for conversion to the ferrous form for absorption. Ninety percent of dietary and 100% of oral iron therapy is in the nonheme form. To the best of our knowledge, the effect of PPIs on iron absorption has not been studied in humans. Our study assessed the relationship between omeprazole therapy and iron absorption in healthy subjects. Materials and Methods: We recruited 9 healthy volunteers between June 2010 and March 2011. Subjects with chronic illness, anemia, or use of PPI therapy were excluded. Serum iron concentrations were measured 1, 2, and 3 h after the ingestion of iron (control group). The measurements were repeated on a subsequent visit after 4 daily oral administrations of omeprazole at a dose of 40 mg (treatment group). Results: One female and 8 male volunteers were enrolled in the study with a mean age of 33 years. There was no statistical difference detected between baseline, 1-h, 2-h, and 3-h iron levels between control and treatment groups. Conclusion: Administration of omeprazole for a short duration does not affect absorption of orally administered iron in healthy individuals.
引用
收藏
页码:307 / 310
页数:4
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