Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats

被引：69
|
作者：
Kagiyama, S
Tsuchihashi, T
Abe, I
Fujishima, M
机构：
[1] Second Dept. of Internal Medicine, Fac. of Medicine, Kyushu University, Fukuoka
来源：
BRAIN RESEARCH | 1997年 / 757卷 / 01期
关键词：
nitric oxide; L-NAME; NOC; 18; medulla oblongata; rats; L-arginine; sympathetic nervous system; arterial pressure;
D O I：
10.1016/S0006-8993(97)00336-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To investigate the cardiovascular role of nitric oxide (NO) in the rostral ventrolateral medulla (RVLM), NOC 18, an NO donor, was microinjected into the RVLM of rats. NOC 18 significantly decreased mean arterial pressure (MAP). Pre-treatment with an NO trapper, carboxy-PTIO, abolished the NOC 18-induced decrease in MAP. Microinjection of L-NAME, an NO synthase inhibitor, increased MAP. L-Arginine reduced MAP and inhibited the presser response induced by L-NAME. Results suggest that NO acts on the RVLM neurons and plays an important role in cardiovascular regulation.
引用
收藏
页码：155 / 158
页数：4
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