Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination

被引：77

作者：

Davis, Carl W. ^{[1
,2
,3
]}

Jackson, Katherine J. L. ^{[4
,9
]}

McCausland, Megan M. ^{[1
,2
,3
]}

Darce, Jaime ^{[5
,10
]}

Chang, Cathy ^{[1
,2
,3
]}

Linderman, Susanne L. ^{[1
,2
,3
]}

Chennareddy, Chakravarthy ^{[1
,2
,3
]}

Gerkin, Rebecca ^{[3
,6
]}

Brown, Shantoria J. ^{[3
,6
]}

Wrammert, Jens ^{[1
,2
,7
]}

Mehta, Aneesh K. ^{[3
,8
]}

Cheung, Wan Cheung ^{[5
,11
]}

Boyd, Scott D. ^{[4
]}

Waller, Edmund K. ^{[3
,6
]}

Ahmed, Rafi ^{[1
,2
,3
]}

机构：

[1] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[3] Emory UGA Ctr Excellence Influenza Res & Surveill, Atlanta, GA USA

[4] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[5] Cell Signaling Technol Inc, Danvers, MA USA

[6] Emory Univ, Sch Med, Winship Canc Inst, Dept Hematol & Oncol, Atlanta, GA USA

[7] Emory Univ, Sch Med, Dept Pediat, Div Infect Dis, Atlanta, GA USA

[8] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA

[9] Garvan Inst Med Res, Div Immunol, Darlinghurst, NSW, Australia

[10] Bluefin BioMed, Beverly, MA USA

[11] Pfizer Inc, Worldwide Res & Dev, BioMed Design, Med Sci, Cambridge, MA USA

来源：

SCIENCE | 2020年 / 370卷 / 6513期

关键词：

MEMORY B-CELL; MONOCLONAL-ANTIBODIES; HUMORAL IMMUNITY; IMMUNOGLOBULIN; CLONING; GENERATION; RESPONSES; DURATION;

D O I：

10.1126/science.aaz8432

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPCs), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPCs 4 weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their prevaccination levels after 1 year. This decline was driven by the loss of BMPCs induced by the vaccine, whereas preexisting BMPCs were maintained. Our results suggest that most BMPCs generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.

引用

页码：237 / +

页数：31

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