Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

被引：470

作者：

Garfall, Alfred L. ^{[1
,4
]}

Maus, Marcela V. ^{[1
,4
]}

Hwang, Wei-Ting ^{[2
,4
]}

Lacey, Simon F. ^{[3
,4
]}

Mahnke, Yolanda D. ^{[3
,4
]}

Melenhorst, J. Joseph ^{[3
,4
]}

Zheng, Zhaohui ^{[3
,4
]}

Vogl, Dan T. ^{[1
,4
]}

Cohen, Adam D. ^{[1
,4
]}

Weiss, Brendan M. ^{[1
,4
]}

Dengel, Karen ^{[4
]}

Kerr, Naseem D. S. ^{[4
]}

Bagg, Adam ^{[3
,4
]}

Levine, Bruce L. ^{[3
,4
]}

June, Carl H. ^{[3
,4
]}

Stadtmauer, Edward A. ^{[1
,4
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2015年 / 373卷 / 11期

关键词：

PLASMA-CELLS; B-CELLS; BONE-MARROW; CHEMOTHERAPY; PLASTICITY; PHENOTYPE; LEUKEMIA;

D O I：

10.1056/NEJMoa1504542

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with refractory multiple myeloma received an infusion of CTL019 cells, a cellular therapy consisting of autologous T cells transduced with an anti-CD19 chimeric antigen receptor, after myeloablative chemotherapy (melphalan, 140 mg per square meter of body-surface area) and autologous stem-cell transplantation. Four years earlier, autologous transplantation with a higher melphalan dose (200 mg per square meter) had induced only a partial, transient response. Autologous transplantation followed by treatment with CTL019 cells led to a complete response with no evidence of progression and no measurable serum or urine monoclonal protein at the most recent evaluation, 12 months after treatment. This response was achieved despite the absence of CD19 expression in 99.95% of the patient's neoplastic plasma cells. (Funded by Novartis and others; ClinicalTrials.gov number, NCT02135406.)

引用

页码：1040 / 1047

页数：8

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