A BODIPY-coumarin-based selective fluorescent probe for rapidly detecting hydrogen sulfide in blood plasma and living cells

被引:45
作者
Qian, Yong [1 ]
Yang, Bingya [1 ]
Shen, Yuning [1 ]
Du, Qianru [1 ]
Lin, Lin [1 ]
Lin, Jie [1 ]
Zhu, Hailiang [1 ]
机构
[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210093, Jiangsu, Peoples R China
关键词
BODIPY; Coumarin; Hydrogen sulfide; Fluorescent probe; Living cells; ANIMATION-LIKE STATE; VERTEBRATE BLOOD; H2S; MICE;
D O I
10.1016/j.snb.2013.03.031
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
We report a sensitive and selective fluorescent probe SFP-BC for hydrogen sulfide detection based on BODIPY-coumarin platform. SFP-BC shows a significant emission increase in the fast response to sulfide at physiological pH. Utilizing this probe, we have successfully detected hydrogen sulfide in fresh mouse blood plasma and in live cells. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:498 / 503
页数:6
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