Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy

被引：360

作者：

Park, Yong Il ^{[2
]}

Kim, Hyung Min ^{[3
]}

Kim, Jeong Hyun ^{[2
]}

Moon, Kyung Chul ^{[1
]}

Yoo, Byeongjun ^{[2
]}

Lee, Kang Taek ^{[3
]}

Lee, Nohyun ^{[2
]}

Choi, Yoonseok ^{[4
]}

Park, Wooram ^{[5
]}

Ling, Daishun ^{[2
]}

Na, Kun ^{[5
]}

Moon, Woo Kyung ^{[4
]}

Choi, Seung Hong ^{[4
]}

Park, Hong Seok ^{[6
]}

Yoon, Soo-Young ^{[1
]}

Suh, Yung Doug ^{[3
]}

Lee, Sung Ho ^{[7
]}

Hyeon, Taeghwan ^{[2
]}

机构：

[1] Korea Univ, Dept Lab Med, Ansan Hosp, Coll Med, Ansan 425707, South Korea

[2] Seoul Natl Univ, World Class Univ WCU Program Chem Convergence Ene, Inst Chem Proc, Sch Chem & Biol Engn, Seoul 151744, South Korea

[3] KRICT, LAMP, Res Ctr Convergence Nanotechnol, Taejon 305600, South Korea

[4] Seoul Natl Univ, Seoul Natl Univ Hosp, Seoul 110744, South Korea

[5] Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea

[6] Korea Univ, Dept Urol, Guro Hosp, Coll Med, Seoul 152703, South Korea

[7] Korea Univ, Dept Thorac & Cardiovasc Surg, Anam Hosp, Coll Med, Seoul 136705, South Korea

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 42期

基金：

新加坡国家研究基金会;

关键词：

luminescence; magnetic resonance imaging; nanoparticles; photodynamic therapy; upconversion; UP-CONVERSION NANOPARTICLES; IRON-OXIDE NANOPARTICLES; QUANTUM DOTS; CONTRAST AGENTS; UPCONVERTING NANOPARTICLES; FLUORESCENT NANOCRYSTALS; NAYF4; NANOCRYSTALS; CANCER; NANOPROBES; NANOPHOSPHORS;

D O I：

10.1002/adma.201202433

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

引用

页码：5755 / 5761

页数：7

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