Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophae rhamnoides L.) berries

被引：133

作者：

Guo, Ruixue ^{[1
]}

Guo, Xinbo ^{[1
,2
]}

Li, Tong ^{[2
]}

Fu, Xiong ^{[1
]}

Liu, Rui Hai ^{[2
]}

机构：

[1] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China

[2] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA

来源：

FOOD CHEMISTRY | 2017年 / 221卷

基金：

中国国家自然科学基金;

关键词：

Sea buckthorn; Phytochemicals; Phenolics; Antioxidant activity; Antiproliferative activity; FLAVONOL GLYCOSIDES; BIOACTIVE COMPOUNDS; ASSAY; COMPONENTS; EXTRACTS; HEALTH; ALPHA; HPLC;

D O I：

10.1016/j.foodchem.2016.11.063

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophae rhamnoides L.). Among the subspecies, Hippophae rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7 +/- 1.3 mg GA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophae rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC50) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：997 / 1003

页数：7

共 30 条

[1] Rapid peroxyl radical scavenging capacity (PSC) assay for assessing both hydrophilic and lipophilic antioxidants [J].

Adom, KK ;

Liu, RH .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (17) :6572-6580

[2] Simultaneous estimation of phenolic acids in sea buckthorn (Hippophae rhamnoides) using RP-HPLC with DAD [J].

Arimboor, Ranjith ;

Kumar, K. Sarin ;

Arumughan, C. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 47 (01) :31-38

[3] Sea buckthorn berries: A potential source of valuable nutrients for nutraceuticals and cosmoceuticals [J].

Bal, Lalit M. ;

Meda, Venkatesh ;

Naik, S. N. ;

Satya, Santosh .

FOOD RESEARCH INTERNATIONAL, 2011, 44 (07) :1718-1727

[4] Sea buckthorn products: Manufacture and composition [J].

Beveridge, T ;

Li, TSC ;

Oomah, BD ;

Smith, A .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (09) :3480-3488

[5] A modified methylene blue assay for accurate cell counting [J].

Felice, Dana L. ;

Sun, Jie ;

Liu, Rui Hai .

JOURNAL OF FUNCTIONAL FOODS, 2009, 1 (01) :109-118

[6] Changes in antioxidant effects and their relationship to phytonutrients in fruits of sea buckthorn (Hippophae rhamnoides L.) during maturation [J].

Gao, XQ ;

Ohlander, M ;

Jeppsson, N ;

Björk, L ;

Trajkovski, V .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (05) :1485-1490

[7] Antiproliferative effects of sea buckthorn (Hippophae rhamnoides L.) extracts on human colon and liver cancer cell lines [J].

Grey, Carl ;

Widen, Cecilia ;

Adlercreutz, Patrick ;

Rumpunen, Kimmo ;

Duan, Rui-Dong .

FOOD CHEMISTRY, 2010, 120 (04) :1004-1010

[8] Effect of Germination on Phytochemical Profiles and Antioxidant Activity of Mung Bean Sprouts (Vigna radiata) [J].

Guo, Xinbo ;

Li, Tong ;

Tang, Kexuan ;

Liu, Rui Hai .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (44) :11050-11055

[9] Sodium Borohydride/Chloranil-Based Assay for Quantifying Total Flavonoids [J].

He, Xiangjiu ;

Liu, Dong ;

Liu, Rui Hai .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (20) :9337-9344

[10] High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate flourescence reader in 96-well format [J].

Huang, DJ ;

Ou, BX ;

Hampsch-Woodill, M ;

Flanagan, JA ;

Prior, RL .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (16) :4437-4444

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