Studies on Photocleavage, DNA Binding, Cytotoxicity, and Docking Studies of Ruthenium(II) Mixed Ligand Complexes

被引：9

作者：

Kumar, Yata Praveen ^{[1
,2
]}

Devi, C. Shobha ^{[2
,3
]}

Srishailam, A. ^{[1
,2
]}

Deepika, N. ^{[1
,2
]}

Kumar, V. Ravi ^{[1
,2
]}

Reddy, P. Venkat ^{[1
,2
]}

Nagasuryaprasad, K. ^{[2
,4
]}

Singh, Surya S. ^{[2
,4
]}

Nagababu, Penumaka ^{[2
,5
]}

Satyanarayana, S. ^{[1
,2
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad, Andhra Pradesh, India

[2] Univ Hyderabad, Sch Chem, Hyderabad, Andhra Pradesh, India

[3] Natl Dong Hwa Univ, Dept Chem, Hualien, Taiwan

[4] Osmania Univ, Dept Biochem, Hyderabad 500007, Andhra Pradesh, India

[5] CSIR Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500007, Telangana State, India

来源：

JOURNAL OF FLUORESCENCE | 2016年 / 26卷 / 06期

关键词：

Polypyridyl hydrazide ligand; Ru(II) complexes; DNA-binding; Anticancer activity; Photocleavage; Docking studies; DOUBLE-HELICAL DNA; CELLULAR UPTAKE; LIGHT SWITCH; PHOTOPHYSICAL PROPERTIES; ELECTRON-TRANSFER; CLEAVAGE; APOPTOSIS; NUCLEAR; PHOTOSENSITIZER; DERIVATIVES;

D O I：

10.1007/s10895-016-1908-y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This article describes the synthesis and characterization of three new Ru(II) polypyridyl complexes including [Ru(phen)(2)(dpphz)](2+) (1), [Ru(bpy)(2)(dpphz)](2+) (2) and [Ru(dmb)(2)(dpphz)](2+) (3) where dpphz = dipyrido[3,2-a:2',3'-c] phenazine-11-hydrazide, phen =1,10-phenanthroline, bpy = 2,2'-bipyridine and dmb = 4,4'-dimethyl2,2'-bipyridine. The binding behaviors of these complexes to calf thymus DNA (CT-DNA) were explored by spectroscopic titrations, viscosity measurements. Results suggest that these complexes can bind to CT-DNA through intercalation. However, their binding strength differs from each other; this may be attributed to difference in the ancillary ligand. The cytotoxicity of 1-3 was evaluated by MTT assay; results indicated that all complexes have significant dose dependent cytotoxicity with HeLa tumor cell line. All complexes exhibited efficient photocleavage of pBR322 DNA upon irradiation. The DNA binding ability of 1-3 was also studied by docking the complexes into B-DNA using docking program.

引用

页码：2119 / 2132

页数：14

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