Echocardiographic evaluation of centenarians in Trieste

被引：3

作者：

Cannata, Antonio ^{[1
,2
,3
]}

Gentile, Piero ^{[1
]}

Paldino, Alessia ^{[1
]}

Nuzzi, Vincenzo ^{[1
]}

Camparini, Luca ^{[2
]}

Ciucci, Giulio ^{[2
]}

Manca, Paolo ^{[1
]}

Artico, Jessica ^{[1
]}

Dal Ferro, Matteo ^{[1
]}

Marcon, Gabriella ^{[4
,5
]}

Tettamanti, Mauro ^{[6
]}

Merlo, Marco ^{[1
]}

Sinagra, Gianfranco ^{[1
]}

Loffredo, Francesco S. ^{[2
,7
]}

机构：

[1] Univ Trieste, Azienda Sanitaria Univ Integrata Trieste ASUITS, Cardiovasc Dept, Trieste, Italy

[2] Int Ctr Genet Engn & Biotechnol, Mol Cardiol, Trieste, Italy

[3] Kings Coll London, Dept Cardiovasc Sci, Fac Life Sci & Med, London, England

[4] Univ Trieste, Azienda Sanitaria Univ Integrata Trieste ASUITS, Dept Med Surg & Hlth Sci, Trieste, Italy

[5] Univ Udine, Dept Med, Udine, Italy

[6] Ist Ric Farmacol Mario Negri, Lab Geriatr Neuropsychiat, Milan, Italy

[7] Univ Campania Luigi Vanvitelli, Dept Translat Med Sci, Div Cardiol, Via L Bianchi, I-80131 Naples, Italy

来源：

JOURNAL OF CARDIOVASCULAR MEDICINE | 2020年 / 21卷 / 08期

关键词：

cardiovascular aging; centenarians; diastolic dysfunction; special populations; DIASTOLIC DYSFUNCTION; HEART-FAILURE; LONGEVITY; OCTOGENARIANS; MORBIDITY; SECRETS; IMPACT;

D O I：

10.2459/JCM.0000000000000984

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Population aging has increased together with the need for cardiovascular care. Understanding the relevance of cardiovascular conditions in the very old is crucial to developing a specific and rationale therapeutic approach. Centenarians can be considered a model of successful aging, although the impact of cardiovascular disease in this population is still unclear. Aim To evaluate the cardiovascular health status of a subset of centenarians enrolled in the Centenari a Trieste study and living in the province of Trieste to describe the prevalence of cardiovascular conditions among them. Methods The current study included 20 individuals born before 1919 and living in the province of Trieste as of 1 May 2019. All centenarians were able to give consent and were subjected to an in-home complete clinical assessment focused on cardiovascular conditions, ECG and echocardiography. Results The majority of centenarians were women (85%) and were not taking any chronic cardiovascular medication (55%). No centenarians had a history of ischemic heart disease while about one-third had signs suggestive of heart failure at examination (20%). Atrial fibrillation was present in 20% of individuals and conduction disorders were uncommon. Although the majority of individuals had a preserved left ventricular function, diastolic function was abnormal in 80% of enrolled centenarians that, however, was mild in 73% of cases. Conclusion This is the second study to perform in-home echocardiography in centenarians and the first to characterize the cardiovascular status of centenarians living in Trieste. The majority of centenarians had asymptomatic diastolic dysfunction and were naive from cardiovascular therapy. The recruitment of new individuals from the Trieste area is continuing to perform analyses on clinical, genetic and environmental factors that may predict greater longevity in this geographical context and unveil mechanisms that regulate cardiac aging associated with increased lifespan.

引用

页码：556 / 561

页数：6

共 32 条

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