MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer

被引：38

作者：

Li, Dengrui ^{[1
]}

Yang, YongHui ^{[2
]}

Zhu, GuiYun ^{[2
]}

Liu, XinYan ^{[3
]}

Zhao, Min ^{[4
]}

Li, XiaoXia ^{[2
]}

Yang, Qinou ^{[2
]}

机构：

[1] Chest Hosp Hebei Prov, Dept Gen Internal Med, Shijiazhuang 050041, Hebei, Peoples R China

[2] Chest Hosp Hebei Prov, Dept Pathol, Shijiazhuang 050041, Hebei, Peoples R China

[3] Chest Hosp Hebei Prov, Dept Oncol 1, Shijiazhuang 050041, Hebei, Peoples R China

[4] Chest Hosp Hebei Prov, Dept Oncol 2, Shijiazhuang 050041, Hebei, Peoples R China

来源：

FEBS LETTERS | 2015年 / 589卷 / 17期

关键词：

Non-small cell lung cancer; microRNA; miR-410; Bromodomain-contajning protein 7; GLIOMA STEM-CELLS; TUMOR-SUPPRESSOR; DOWN-REGULATION; EXPRESSION; GLIOBLASTOMA; BROMODOMAIN; SENESCENCE; GROWTH; EZH2;

D O I：

10.1016/j.febslet.2015.06.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

miR-410 acts as an oncogene or tumor suppressor gene in some malignancies. However, its role in NSCLC is still unknown. In this study, we showed that the expression of miR-410 was up-regulated in both human NSCLC tissues and cells. Overexpression of miR-410 promoted cell proliferation, migration, and invasion of NSCLC. In addition, bromodomain-containing protein 7 (BRD7) was a direct target of miR-410. MiR-410-mediated downregulation of BRD7 led to increase Akt phosphorylation. Inhibition of Akt phosphorylation can rescue the effect of miR-410 on NSCLC cell. The expression of BRD7 was downregulated in NSCLC and was inversely expressed with miR-410 in NSCLC. Our data provided new knowledge regarding the role of miR-410 in the lung cancer progression. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2218 / 2223

页数：6

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