Synthesis of Chlorin-Sensitized Near Infrared-Emitting Lanthanide Complexes

被引：27

作者：

Laakso, Johanna ^{[1
]}

Rosser, Geraldine A. ^{[2
]}

Szijjarto, Csongor ^{[3
]}

Beeby, Andrew ^{[2
]}

Borbas, K. Eszter ^{[1
,3
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

[2] Univ Durham, Dept Chem, Durham DH1 3LE, England

[3] Uppsala Univ, Dept Chem BMC, SE-75123 Uppsala, Sweden

来源：

INORGANIC CHEMISTRY | 2012年 / 51卷 / 19期

基金：

瑞典研究理事会; 英国工程与自然科学研究理事会;

关键词：

SPARSELY SUBSTITUTED CHLORINS; CHLOROPHYLL ANALOG CHEMISTRY; VISIBLE-LIGHT SENSITIZATION; MOLECULAR IMAGING PROBES; C-METHYLATED CHLORINS; ENERGY-TRANSFER DYADS; DE-NOVO SYNTHESIS; PORPHYRIN SENSITIZATION; BIOSYNTHETIC RESEARCH; CONTRAST AGENTS;

D O I：

10.1021/ic3015354

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lanthanide (Yb3+, Nd3+) complexes equipped with red-absorbing hydroporphyrin (chlorin) antennae were synthesized and characterized. The syntheses are scalable, highly modular, and enable the introduction of different chlorins functionalized with a single reactive group (COOH or NH2). Absorption maxima were dependent on chlorin substitution pattern (monomeso aryl or dimeso aryl) and metalation state (free base or zinc chelate). The complexes benefit from dual chlorin (610-639 nm) and lanthanide (980 or 1065 nm for Yb- or Nd-complexes, respectively) emission in the biologically relevant red and near IR region of the spectrum.

引用

页码：10366 / 10374

页数：9

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