The CPTAC Data Portal: A Resource for Cancer Proteomics Research

被引：311

作者：

Edwards, Nathan J. ^{[1
]}

Oberti, Mauricio ^{[3
]}

Thangudu, Ratna R. ^{[3
]}

Cai, Shuang ^{[3
]}

McGarvey, Peter B. ^{[1
,2
]}

Jacob, Shine ^{[3
]}

Madhavan, Subha ^{[2
]}

Ketchum, Karen A. ^{[3
]}

机构：

[1] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA

[2] Georgetown Univ, Innovat Ctr Biomed Informat, Washington, DC 20007 USA

[3] ESAC Inc, Rockville, MD 20850 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2015年 / 14卷 / 06期

关键词：

Data portal; Clinical Proteomics Tumor Analysis Consortium; mass spectrometry; proteomics; The Cancer Genome Atlas; REPRODUCIBILITY;

D O I：

10.1021/pr501254j

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Clinical Proteomic Tumor Analysis Consortium (CPTAC), under the auspices of the National Cancer Institute's Office of Cancer Clinical Proteomics Research, is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of proteomic technologies and workflows to clinical tumor samples with characterized genomic and transcript profiles. The consortium analyzes cancer biospecimens using mass spectrometry, identifying and quantifying the constituent proteins and characterizing each tumor sample's proteome. Mass spectrometry enables highly specific identification of proteins and their isoforms, accurate relative quantitation of protein abundance in contrasting biospecimens, and localization of post-translational protein modifications, such as phosphorylation, on a protein's sequence. The combination of proteomics, transcriptomics, and genomics data from the same clinical tumor samples provides an unprecedented opportunity for tumor proteogenomics. The CPTAC Data Portal is the centralized data repository for the dissemination of proteomic data collected by Proteome Characterization Centers (PCCs) in the consortium. The portal currently hosts 6.3 TB of data and includes proteomic investigations of breast, colorectal, and ovarian tumor tissues from The Cancer Genome Atlas (TCGA). The data collected by the consortium is made freely available to the public through the data portal.

引用

页码：2707 / 2713

页数：7

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