RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas (Retracted article. See vol. 41, pg. 1198, 2023)

被引：241

作者：

Zhang, Xinwei ^{[1
,2
,5
]}

Zhao, Xiaohong ^{[1
,2
]}

Fiskus, Warren ^{[6
]}

Lin, Jianhong ^{[7
]}

Lwin, Tint ^{[1
,2
]}

Rao, Rekha ^{[6
]}

Zhang, Yizhuo ^{[5
]}

Chan, John C. ^{[8
]}

Fu, Kai ^{[8
]}

Marquez, Victor E. ^{[9
]}

Chen-Kiang, Selina ^{[10
]}

Moscinski, Lynn C. ^{[1
,2
]}

Seto, Edward ^{[3
]}

Dalton, William S. ^{[1
,2
]}

Wright, Kenneth L. ^{[4
]}

Sotomayor, Eduardo ^{[1
,2
]}

Bhalla, Kapil ^{[6
]}

Tao, Jianguo ^{[1
,2
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL 33613 USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Expt Therapeut Program, Tampa, FL 33613 USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Mol Oncol Program, Tampa, FL 33613 USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Immunol Program, Tampa, FL 33613 USA

[5] Tianjin Canc Hosp, Dept Immunol & Malignant Hematol, Tianjin 300060, Peoples R China

[6] Univ Kansas, Ctr Canc, Kansas City, KS 66160 USA

[7] Dana Farber Canc Inst, Boston, MA 02115 USA

[8] Univ Nebraska Med Ctr, Dept Pathol, Omaha, NE 68198 USA

[9] NCI, Chem Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA

[10] Weill Cornell Med Coll, Dept Pathol, New York, NY 10065 USA

来源：

CANCER CELL | 2012年 / 22卷 / 04期

关键词：

MANTLE-CELL; EXPRESSION; REPRESSION; RECRUITMENT; DEACETYLASE; CANCER;

D O I：

10.1016/j.ccr.2012.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2. MYC contributes to EZH2 upregulation via repression of the EZH2 targeting miR-26a, and EZH2 induces MYC via inhibition of the MYC targeting miR-494 to create positive feedback. Combined inhibition of HDAC3 and EZH2 cooperatively disrupted the MYC-EZH2-miR-29 axis, resulting in restoration of miR-29 expression, downregulation of miR-29-targeted genes, and lymphoma growth suppression in vitro and in vivo. These findings define a MYC-mediated miRNA repression mechanism, shed light on MYC lymphomagenesis mechanisms, and reveal promising therapeutic targets for aggressive B-cell malignancies.

引用

页码：506 / 523

页数：18

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