A High-Yield and Cost-Effective Synthesis of Spirotetramat

被引：2

作者：

Xu, Guiqing ^{[1
]}

Wang, Jiahao ^{[1
]}

Zhou, Yingjie ^{[1
]}

Mao, Longfei ^{[1
]}

机构：

[1] Henan Normal Univ, Henan Engn Res Ctr Chiral Hydroxyl Pharmaceut, Xinxiang 453007, Henan, Peoples R China

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 10期

关键词：

cis-8-methoxy-1,3-diazaspiro[4.5]decane-2,4-dione; spirotetramat; synthesis; TETRONIC ACID-DERIVATIVES; INSECTICIDAL ACTIVITY; DESIGN;

D O I：

10.1134/S1070428020100176

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione, the key intermediate in the synthesis of spirotetramat, was synthesized by catalytic hydrogenation, oxidation, and Bucherer-Bergs reaction with 4-methoxycyclohexan-1-one as raw material. Spirotetramat was obtained in an overall yield of 20.4% by a multi-step reaction sequence including hydrolysis, esterification, acylation, intramolecular condensation, and O-acylation. The advantages of the proposed method are mild conditions, simple operation, and good to excellent yields in each step.

引用

页码：1775 / 1778

页数：4

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