Diffusion Tensor MRI Evaluation of the Corona Radiata, Cingulate Gyri, and Corpus Callosum in HIV Patients

被引:38
作者
Leite, Sarah C. B. [1 ]
Correa, Diogo G. [1 ]
Doring, Thomas M. [1 ,2 ]
Kubo, Tadeu T. A. [1 ,2 ]
Netto, Tania M. [1 ]
Ferracini, Rafael [2 ]
Ventura, Nina [1 ,2 ]
Bahia, Paulo R. V. [1 ]
Gasparetto, Emerson L. [1 ,2 ]
机构
[1] Univ Fed Rio de Janeiro, Dept Radiol, BR-21941913 Rio De Janeiro, RJ, Brazil
[2] CDPI, Rio De Janeiro, Brazil
关键词
DTI; normal appearing white matter; HIV; corpus callosum; corona radiata; cingulate gyri; WHITE-MATTER ABNORMALITIES; INFECTION; BRAIN;
D O I
10.1002/jmri.24129
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PurposeTo evaluate the white matter integrity of the corona radiata, cingulate gyri, and corpus callosum in patients with human immunodeficiency virus (HIV) infection through diffusion tensor imaging (DTI). Materials and MethodsThirty-four patients with at least 5 years of HIV infection and 27 healthy controls underwent magnetic resonance imaging (MRI) in a 1.5 T scanner. A voxelwise-based technique was used to analyze the DTI data. ResultsWe found that in the body of corpus callosum the fractional anisotropy (FA) was significantly reduced, whereas mean diffusivity (MD) and radial diffusivity (RD) were increased in HIV patients. Analyzing the corona radiata, axial diffusivity (AD) and MD were significantly increased in the left superior region, MD and RD were increased in the left posterior area, and, furthermore, MD was also increased in the right posterior region. No significant abnormalities were found on the cingulate gyri. The white matter damage, related to FA reduction, was associated with increased RD, indicating that demyelization might be the pathophysiological result of this damage. ConclusionSince the DTI can detect abnormalities in the normal-appearing white matter, this technique may play a role as an early marker of HIV disease progression, including clinical manifestations such as cognitive impairment.
引用
收藏
页码:1488 / 1493
页数:6
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