Hepatitis B virus X protein in the proliferation of hepatocellular carcinoma cells

被引：10

作者：

Gong, Peng ^{[1
]}

Zhang, Xianbin ^{[1
]}

Zhang, Jian ^{[1
]}

Zhang, Jing ^{[1
]}

Luo, Haifeng ^{[1
]}

Wang, Zhongyu ^{[1
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 222 Zhongshan Rd, Dalian 116011, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2013年 / 18卷

基金：

中国国家自然科学基金;

关键词：

Hepatocellular Carcinoma; Hepatitis B virus X protein; proliferation; Review; NF-KAPPA-B; GENE-EXPRESSION PROFILES; LIVER-CANCER; GROWTH-FACTOR; UP-REGULATION; HBX GENE; ACTIVATION; TRANSCRIPTION; PATHWAYS; SURVIVAL;

D O I：

10.2741/4177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the most common and deadly malignant neoplasms worldwide. Chronic hepatitis B virus (HBV) infection is closely associated with the occurrence of HCC. The HBV genome encodes a ubiquitous transactivator, termed the HBV X protein (HBx), that is essential for HBV replication in vivo. HBx is involved in multiple steps of carcinoma development. Even in the preneoplastic stage, HBx acts as a tumor promoter. HBx participates in several mechanisms that have been linked to cell proliferation, including gene transcription, cell cycle regulation, and several signaling pathways. Moreover, HBx mutants, especially those with mutations in the COOH-terminal end, have been implicated in hepatocarcinogenesis. Therefore, therapeutic strategies targeting HBx could be effective at multiple stages of HCC development, even as early as the preneoplastic stage.

引用

页码：1256 / 1265

页数：10

共 102 条

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