Detection of Circulating Tumor Cells Using Microfluidics

被引：50

作者：

Burinaru, Tiberiu A. ^{[1
]}

Avram, Marioara ^{[1
]}

Avram, Andrei ^{[1
]}

Marculescu, Catalin ^{[1
]}

Tincu, Bianca ^{[1
]}

Tucureanu, Vasilica ^{[1
]}

Matei, Alina ^{[1
]}

Militaru, Manuella ^{[2
]}

机构：

[1] IMT Bucharest, Natl Inst R&D Microtechnol, Bucharest 077190, Romania

[2] Univ Agron Sci & Vet Med, Bucharest 050097, Romania

来源：

ACS COMBINATORIAL SCIENCE | 2018年 / 20卷 / 03期

关键词：

circulating tumor cells; microfluidics; lab-on-a-chip; metastasis; epithelial-mesenchymal transition; METASTATIC-BREAST-CANCER; GUANYLYL CYCLASE-C; EPITHELIAL-MESENCHYMAL TRANSITION; PERIPHERAL-BLOOD; MOLECULAR-MECHANISMS; EMBEDDED MICROCHIPS; PROGNOSTIC-FACTOR; PROSTATE-CANCER; WHOLE-BLOOD; STEM-CELLS;

D O I：

10.1021/acscombsci.7b00146

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Metastasis is the main cause of death in cancer patients worldwide. During metastasis, cancer cells detach from the primary tumor and invade distant tissue. The cells that undergo this process are called circulating tumor cells (CTCs). Studies show that the number of CTCs in the peripheral blood can predict progression-free survival and overall survival and can be informative concerning the efficacy of treatment. Research is now concentrated on developing devices that can detect CTCs in the blood of cancer patients with improved sensitivity and specificity that can lead to improved clinical evaluation. This review focuses on devices that detect and capture CTCs using different cell properties (surface markers, size, deformability, electrical properties, etc.). We also discuss the process of tumor cell dissemination, the biology of CTCs, epithelial-mesenchymal transition (EMT), and several challenges and clinical applications of CTC detection.

引用

页码：107 / 126

页数：20

共 150 条

[1] Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor [J].

Adams, Andre A. ;

Okagbare, Paul I. ;

Feng, Juan ;

Hupert, Matuesz L. ;

Patterson, Don ;

Goettert, Jost ;

McCarley, Robin L. ;

Nikitopoulos, Dimitris ;

Murphy, Michael C. ;

Soper, Steven A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (27) :8633-8641

[2] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[3] OPINION Challenges in circulating tumour cell research [J].

Alix-Panabieres, Catherine ;

Pantel, Klaus .

NATURE REVIEWS CANCER, 2014, 14 (09) :623-631

[4]

Alix-Panabieres Catherine, 2012, Recent Results Cancer Res, V195, P69, DOI 10.1007/978-3-642-28160-0_6

[5] Separation of tumor cells with dielectrophoresis-based microfluidic chip [J].

Alshareef, Mohammed ;

Metrakos, Nicholas ;

Perez, Eva Juarez ;

Azer, Fadi ;

Yang, Fang ;

Yang, Xiaoming ;

Wang, Guiren .

BIOMICROFLUIDICS, 2013, 7 (01)

[6] MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing [J].

Ambros, V .

CELL, 2003, 113 (06) :673-676

[7] Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers [J].

Armstrong, Andrew J. ;

Marengo, Matthew S. ;

Oltean, Sebastian ;

Kemeny, Gabor ;

Bitting, Rhonda L. ;

Turnbull, James D. ;

Herold, Christina I. ;

Marcom, Paul K. ;

George, Daniel J. ;

Garcia-Blanco, Mariano A. .

MOLECULAR CANCER RESEARCH, 2011, 9 (08) :997-1007

[8]

Ashworth T. R., 1869, AUST MED J, V14, P146

[9]

Avram A, 2012, INT SEMICONDUCT CON, V2, P165, DOI 10.1109/SMICND.2012.6400666

[10] Gold Nanoparticle Uptake by Tumour Cells of B16 Mouse Melanoma [J].

Avram, Marioara ;

Balan, Catalin Mihai ;

Petrescu, Ina ;

Schiopu, Vasilica ;

Marculescu, Catalin ;

Avram, Andrei .

PLASMONICS, 2012, 7 (04) :717-724

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