Long noncoding RNA THOR is highly expressed in colorectal cancer and predicts a poor prognosis

被引：7
作者：
Chu, Feifei [1 ]
Cui, Yuanbo [2 ]
Li, Kunkun [1 ]
Xiao, Xingguo [1 ]
Zhang, Li [1 ]
Zhang, Lei [1 ]
Wang, Lihong [1 ]
Gao, Lei [3 ]
Yin, Ningwei [4 ]
Wu, Huili [1 ]
机构：
[1] Zhengzhou Univ, Dept Gastroenterol, Zhengzhou Cent Hosp, Zhengzhou 450007, Peoples R China
[2] Zhengzhou Univ, Translat Med Ctr, Zhengzhou Cent Hosp, Zhengzhou 450007, Peoples R China
[3] Zhengzhou Univ, Dept Gastrointestinal Surg, Zhengzhou Cent Hosp, Zhengzhou 450007, Peoples R China
[4] Zhengzhou Univ, Dept Sci & Educ, Zhengzhou Cent Hosp, Zhengzhou 450007, Peoples R China
来源：
FUTURE ONCOLOGY | 2020年 / 16卷 / 25期
关键词：
colorectal cancer; proliferation; survival; THOR; MESSENGER-RNA; LNCRNA; STATISTICS; INCREASES; STEMNESS; CELLS;
D O I：
10.2217/fon-2020-0393
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. This study aimed to investigate the role of long noncoding RNA THOR in CRC. Materials & methods: The expression of THOR in 103 cases of CRC tissues and four CRC cell lines was examined by quantitative real-time PCR. Cell counting kit-8 and colony formation assays were applied to detect cell proliferation, and flow cytometry was used for testing cell cycle and apoptosis of CRC. Results: We found that THOR was highly expressed in CRC and correlated with tumor node metastasis stage, histological subtype, tumor size and differentiation and survival in CRC patients. Meanwhile, knockdown of THOR significantly suppressed cell proliferation and cell cycle of CRC, whereas promoted cell apoptosis. Conclusion: Our findings suggest that THOR is an oncogenic long noncoding RNA in CRC and a potential prognostic biomarker for this cancer.
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收藏
页码：1911 / 1920
页数：10
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