Design, synthesis and insecticidal activities of novel acetamido derivatives containing N-pyridylpyrazole carboxamides

被引：37

作者：

Kang, Shenghong ^{[1
]}

Song, Baoan ^{[1
]}

Wu, Jian ^{[1
]}

He, Ming ^{[1
]}

Hu, Deyu ^{[1
]}

Jin, Linhong ^{[1
]}

Zeng, Song ^{[1
]}

Xue, Wei ^{[1
]}

Yang, Song ^{[1
]}

机构：

[1] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Res & Dev Ctr Fine Chem,Minist Educ, Guiyang 550025, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 67卷

基金：

中国国家自然科学基金;

关键词：

Acetamido derivatives; N-pyridylpyrazole carboxamides; Synthesis; Insecticidal activity; ANTHRANILIC DIAMIDE INSECTICIDE; DIAMONDBACK MOTH LEPIDOPTERA; BIOLOGICAL-ACTIVITIES; RESISTANCE; ANALOGS; AMIDES; ACIDS;

D O I：

10.1016/j.ejmech.2013.06.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel acetamido derivatives containing N-pyridylpyrazole carboxamides was designed and synthesized by increasing the amide bridge of chlorantraniliprole using acetamido moieties and introducing different aryl substitutions. The target compounds were characterized by H-1 NMR, C-13 NMR, IR, and elemental analysis. Bioassays indicated that some of the synthesized compounds exhibited strong insecticidal activity against Plutella xylostella. Compounds 5e, 5g and 5v were the most potent, with LC50 values of 23.72, 2.04, and 20.01 mg/L, respectively. The insecticidal activity of compound 5g was higher than that of chlorpyrifos (LC50 = 7.25 mg/L), a commonly used insecticide. These results indicate that novel acetamido derivatives containing N-pyridylpyrazole carboxamides can effectively control P. xylostella. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：14 / 18

页数：5

共 45 条

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