Proteasomes and their kin: Proteases in the machine age

被引：561
作者：
Pickart, CM
Cohen, RE
机构：
[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA
[2] Univ Iowa, Coll Med, Dept Biochem, Iowa City, IA 52242 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1336
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
'Chambered proteases', including the eukaryotic 26S proteasome, use the energy of ATP to drive the unfolding and translocation of a polypeptide substrate into a chamber of sequestered proteolytic active sites. These proteases have diverse functions and are found in all three kingdoms of life. Understanding chambered proteases requires answers to two questions - how do these remarkable machines select the correct target proteins and how do they bring about the processive degradation of these molecules?
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收藏
页码：177 / 187
页数：11
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