Why are some individuals resistant to the cardioprotective effects of aspirin?: Could it be thromboxane A2?

被引:92
作者
Halushka, MK
Halushka, PV
机构
[1] Med Univ S Carolina, Dept Pharmacol, Charleston, SC 29425 USA
[2] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA
关键词
editorials; aspirin; thromboxane;
D O I
10.1161/01.CIR.0000015422.86569.52
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1620 / 1622
页数:3
相关论文
共 20 条
[1]   Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. [J].
Bombardier, C ;
Laine, L ;
Reicin, A ;
Shapiro, D ;
Burgos-Vargas, R ;
Davis, B ;
Day, R ;
Ferraz, MB ;
Hawkey, CJ ;
Hochberg, MC ;
Kvien, TK ;
Schnitzer, TJ ;
Weaver, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (21) :1520-1528
[2]   The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice - Evidence that eicosanoids other than thromboxane contribute to atherosclerosis [J].
Cayatte, AJ ;
Du, Y ;
Oliver-Krasinski, J ;
Lavielle, G ;
Verbeuren, TJ ;
Cohen, RA .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (07) :1724-1728
[3]   Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E2-dependent plaque instability [J].
Cipollone, F ;
Prontera, C ;
Pini, B ;
Marini, M ;
Fazia, M ;
De Cesare, D ;
Iezzi, A ;
Ucchino, S ;
Boccoli, G ;
Saba, V ;
Chiarelli, F ;
Cuccurullo, F ;
Mezzetti, A .
CIRCULATION, 2001, 104 (08) :921-927
[4]   Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina [J].
Cipollone, F ;
Patrignani, P ;
Greco, A ;
Panara, MR ;
Padovano, R ;
Cuccurullo, F ;
Patrono, C ;
Rebuzzi, AG ;
Liuzzo, G ;
Quaranta, G ;
Maseri, A .
CIRCULATION, 1997, 96 (04) :1109-1116
[5]  
CRAVEN L L, 1953, Miss Valley Med J, V75, P38
[6]  
DAVISBRUNO KL, 1994, ADV DRUG RES, V25, P173
[7]   Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events [J].
Eikelboom, JW ;
Hirsh, J ;
Weitz, JI ;
Johnston, M ;
Yi, Q ;
Yusuf, S .
CIRCULATION, 2002, 105 (14) :1650-1655
[8]   THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].
HAMBERG, M ;
SVENSSON, J ;
SAMUELSSON, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998
[9]  
JAEK DB, 1997, LANCET, V350, P437
[10]   Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib [J].
Konstam, MA ;
Weir, MR ;
Reicin, A ;
Shapiro, D ;
Sperling, RS ;
Barr, E ;
Gertz, BJ .
CIRCULATION, 2001, 104 (19) :2280-2288