Cannabinoids and Neuropathic Pain

被引：29
作者：
Goya, P. [1 ]
Jagerovic, N. [1 ]
Hernandez-Folgado, L. [1 ]
Martin, M. I. [2 ]
机构：
[1] CSIC, Inst Quim Med, C Juan de la Cierva 3, E-28006 Madrid, Spain
[2] Univ Rey Juan Carlos, Area Farmacol, Fac Ciencias Salud, E-28922 Madrid, Spain
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 07期
关键词：
Cannabinoid; neuropathic pain; analgesia;
D O I：
10.2174/1389557033487818
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
After a brief overview of the endocannabinoid system (CB receptors, and endocannabinoids) and of the cannabinergic ligands, some general issues related to cannabinoids and pain are commented. Finally, the most important findings regarding cannabinoids and neuropathic pain are discussed in detail.
引用
收藏
页码：765 / 772
页数：8
相关论文
共 96 条
[1]   (R)-METHANANDAMIDE - A CHIRAL NOVEL ANANDAMIDE POSSESSING HIGHER POTENCY AND METABOLIC STABILITY [J].
ABADJI, V ;
LIN, SY ;
TAHA, G ;
GRIFFIN, G ;
STEVENSON, LA ;
PERTWEE, RG ;
MAKRIYANNIS, A .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) :1889-1893
[2]  
ADAMS IB, 1995, J PHARMACOL EXP THER, V273, P1172
[3]   Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor [J].
Barnett-Norris, J ;
Hurst, DP ;
Lynch, DL ;
Guarnieri, F ;
Makriyannis, A ;
Reggio, PH .
JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (17) :3649-3659
[4]   Functional role of high-affinity anandamide transport, as revealed by selective inhibition [J].
Beltramo, M ;
Stella, N ;
Calignano, A ;
Lin, SY ;
Makriyannis, A ;
Piomelli, D .
SCIENCE, 1997, 277 (5329) :1094-1097
[5]   TIME-RELATED DECREASES IN MU AND DELTA OPIOID RECEPTORS IN THE SUPERFICIAL DORSAL HORN OF THE RAT SPINAL-CORD FOLLOWING A LARGE UNILATERAL DORSAL RHIZOTOMY [J].
BESSE, D ;
LOMBARD, MC ;
BESSON, JM .
BRAIN RESEARCH, 1992, 578 (1-2) :115-121
[6]   Inhibition of tumor angiogenesis by cannabinoids [J].
Blázquez, C ;
Casanova, ML ;
Planas, A ;
del Pulgar, TG ;
Villanueva, C ;
Fernández-Aceñero, MJ ;
Aragonés, J ;
Huffman, JW ;
Jorcano, JL ;
Guzmán, M .
FASEB JOURNAL, 2003, 17 (01) :529-+
[7]   Fatty acid amide hydrolase substrate specificity [J].
Boger, DL ;
Fecik, RA ;
Patterson, JE ;
Miyauchi, H ;
Patricelli, MP ;
Cravatt, BF .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (23) :2613-2616
[8]   α-Keto heterocycle inhibitors of fatty acid amide hydrolase:: Carbonyl group modification and α-substitution [J].
Boger, DL ;
Miyauchi, H ;
Hedrick, MP .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (12) :1517-1520
[9]   Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling [J].
Bracey, MH ;
Hanson, MA ;
Masuda, KR ;
Stevens, RC ;
Cravatt, BF .
SCIENCE, 2002, 298 (5599) :1793-1796
[10]   Evidence for a new G protein-coupled cannabinoid receptor in mouse brain [J].
Breivogel, CS ;
Griffin, G ;
Di Marzo, V ;
Martin, BR .
MOLECULAR PHARMACOLOGY, 2001, 60 (01) :155-163
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